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SB705498 - 98%, high purity , Vanilloid receptor antagonist, CAS No.501951-42-4, Vanilloid receptor antagonist

Moligand™
≥98%

CAS#: 501951-42-4
Formula: C₁₇H₁₆BrF₃N₄O
Molecular Weight: 429.23
PubChem CID: 9910486

Item Number

S126833

Grouped product items
SKU	Size	Availability	Price
S126833-1mg	1mg	In stock	$20.90
S126833-5mg	5mg	In stock	$86.90
S126833-10mg	10mg	In stock	$162.90
S126833-25mg	25mg	In stock	$366.90
S126833-50mg	50mg	In stock	$706.90
S126833-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,142.90

View related series

TRPV1 Channel blocker

Basic Description

Synonyms	SB-705498\|501951-42-4\|SB705498\|(R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea\|SB 705498\|1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea\|T74V9O0Y2W\|GSK705498\|N-(2-bromophenyl)-N'-[(3R)-1-[
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	SB-705498 is a potent, selective and transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC50 of 7.1. SB-705498 potently inhibits capsaicin-induced activation of human TRPV1 expressed in 1321N1 cells or HEK293 cells with apparent
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST, CHANNEL BLOCKER
Mechanism of action	Vanilloid receptor antagonist

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 2 Activities

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM8 Tclin Transient receptor potential cation channel subfamily M member 8 0 Activities

Discover Target: TRPM8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea
INCHI	InChI=1S/C17H16BrF3N4O/c18-13-3-1-2-4-14(13)24-16(26)23-12-7-8-25(10-12)15-6-5-11(9-22-15)17(19,20)21/h1-6,9,12H,7-8,10H2,(H2,23,24,26)/t12-/m1/s1
InChi Key	JYILLRHXRVTRSH-GFCCVEGCSA-N
Canonical SMILES	C1CN(CC1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F
Isomeric SMILES	C1CN(C[C@@H]1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F
PubChem CID	9910486
Molecular Weight	429.23

PubChem CID

9910486

CAS Registry No.

501951-42-4

ChEMBL Ligand

CHEMBL207433

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
A2211546	Certificate of Analysis	Oct 13, 2023	S126833
A2211561	Certificate of Analysis	Oct 13, 2023	S126833
A2211599	Certificate of Analysis	Oct 13, 2023	S126833
A2211603	Certificate of Analysis	Oct 13, 2023	S126833
A2211830	Certificate of Analysis	Oct 13, 2023	S126833
A2211839	Certificate of Analysis	Oct 13, 2023	S126833

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