| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S661711-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $550.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC 50 of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinet IC50& Target:IC 50 : 42 nM (TAO3), 237 nM (MEKK3) In Vitro:SBI-581 shows moderate selectivity (> 5-10x) against the majority of a broad panel of kinases. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo:SBI-581 (10mg/kg, IP, once) displays reasonable pharmacokinetics (t 1/2 =1.5 hr; AUC= 1202 hr*ng/mL; Cmax= ~2 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:SBI-581 is an orally active and potent selective serine-threonine kinase TAO3 inhibitor, with an IC 50 of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinet |
| Canonical SMILES | O=C1/C(C2=C(C=CC=C2C#CC3(O)CCNCC3)N1)=C\\C4=CC5=C(N4)C=CC=C5 |
|---|---|
| Molecular Weight | 383.44 |
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