SBP-7455 - 95%, high purity , CAS No.1884222-74-5, Inhibitor of unc-51 like autophagy activating kinase 1;Inhibitor of unc-51 like autophagy activating kinase 2

Item Number

S412916

Grouped product items
SKU	Size	Availability	Price
S412916-5mg	5mg	In stock	$162.90
S412916-10mg	10mg	In stock	$271.90
S412916-25mg	25mg	In stock	$489.90
S412916-50mg	50mg	In stock	$706.90
S412916-100mg	100mg	In stock	$1,033.90
S412916-250mg	250mg	In stock	$2,326.90

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Basic Description

Specifications & Purity	95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of unc-51 like autophagy activating kinase 1;Inhibitor of unc-51 like autophagy activating kinase 2
Product Description	Information SBP-7455 (compound 26) is a dual inhibitor of ULK1 and ULK2 that potently inhibits ULK1/2 enzymatic activity in vitro and in vivo. SBP-7455 inhibits starvation-induced autophagic flux in TNBC cells.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-N-cyclopropyl-2-N-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
INCHI	InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)
InChi Key	BQROJYIEHOOQBY-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C(C=C1)NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)OC
Isomeric SMILES	COC1=C(C=C(C=C1)NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)OC
PubChem CID	132178569
Molecular Weight	354.33

Certificates

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6 results found

Lot Number	Certificate Type	Date	Item
L2212141	Certificate of Analysis	Nov 04, 2022	S412916
L2212142	Certificate of Analysis	Nov 04, 2022	S412916
L2212143	Certificate of Analysis	Nov 04, 2022	S412916
L2212144	Certificate of Analysis	Nov 04, 2022	S412916
L2212145	Certificate of Analysis	Nov 04, 2022	S412916
L2212146	Certificate of Analysis	Nov 04, 2022	S412916

References

1. Ren H, Bakas NA, Vamos M, Chaikuad A, Limpert AS, Wimer CD, Brun SN, Lambert LJ, Tautz L, Celeridad M et al.. (2020) Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.. J Med Chem, 63 (23): (14609-14625). [PMID:33200929]

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Basic Description