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SBP-7455 , CAS No.S613474, Inhibitor of unc-51 like autophagy activating kinase 1;Inhibitor of unc-51 like autophagy activating kinase 2

  • Moligand™
Item Number
S613474
Grouped product items
SKUSizeAvailabilityPrice Qty
S613474-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
S613474-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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unc-51 like autophagy activating kinase 1 Inhibitor unc-51 like autophagy activating kinase 2 Inhibitor

Basic Description

Synonymscompound 26;SBP7455
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of unc-51 like autophagy activating kinase 1;Inhibitor of unc-51 like autophagy activating kinase 2

Associated Targets

ULK1 Tchem Serine/threonine-protein kinase ULK1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ULK2 Tchem Serine/threonine-protein kinase ULK2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
INCHI InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)
InChi Key BQROJYIEHOOQBY-UHFFFAOYSA-N
Canonical SMILES COc1cc(ccc1OC)Nc1ncc(c(n1)NC1CC1)C(F)(F)F
Isomeric SMILES COC1=C(C=C(C=C1)NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)OC
PubChem CID 132178569

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Ren H, Bakas NA, Vamos M, Chaikuad A, Limpert AS, Wimer CD, Brun SN, Lambert LJ, Tautz L, Celeridad M et al..  (2020)  Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer..  J Med Chem,  63  (23): (14609-14625).  [PMID:33200929]

Solution Calculators

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