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SC 22716 - ≥98%, high purity , CAS No.262451-89-8, Inhibitor of Leukotriene A 4 hydrolase

  • Moligand™
  • ≥98%
Item Number
S356867
Grouped product items
SKUSizeAvailabilityPrice Qty
S356867-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$86.90
S356867-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$258.90
S356867-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$449.90
S356867-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,029.90
S356867-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,437.90
S356867-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,299.90

Basic Description

Synonyms262451-89-8|1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine|SC 22716|SC-22716|CHEMBL119054|Pyrrolidine, 1-[2-([1,1'-biphenyl]-4-yloxy)ethyl]-|GTPL9102|SCHEMBL1899201|DTXSID50438298|BDBM50085251|AKOS025295019|NCGC00165874-01|HY-118795|1-[2-(Biphenyl-4-yloxy)-ethyl
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Leukotriene A 4 hydrolase
Product Description

Cell-permeable leukotriene A4 (LTA4) hydrolase inhibitor which suppresses the production of LTB4. It is implicated in the pathogenesis of many diseases including inflammatory bowel disease and psoriasis.

Associated Targets

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LTA4H Tchem Leukotriene A-4 hydrolase 5 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine
INCHI InChI=1S/C18H21NO/c1-2-6-16(7-3-1)17-8-10-18(11-9-17)20-15-14-19-12-4-5-13-19/h1-3,6-11H,4-5,12-15H2
InChi Key PKUGRVAJRGZDJP-UHFFFAOYSA-N
Canonical SMILES C1CCN(C1)CCOC2=CC=C(C=C2)C3=CC=CC=C3
Isomeric SMILES C1CCN(C1)CCOC2=CC=C(C=C2)C3=CC=CC=C3
WGK Germany 3
PubChem CID 10333202
Molecular Weight 267.37

Certificates

Certificate of Analysis(COA)

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12 results found

Lot NumberCertificate TypeDateItem
H2415514Certificate of AnalysisApr 30, 2024 S356867
H2415515Certificate of AnalysisApr 30, 2024 S356867
H2415516Certificate of AnalysisApr 30, 2024 S356867
H2415517Certificate of AnalysisApr 30, 2024 S356867
H2415518Certificate of AnalysisApr 30, 2024 S356867
H2415519Certificate of AnalysisApr 30, 2024 S356867
H2415520Certificate of AnalysisApr 30, 2024 S356867
H2415521Certificate of AnalysisApr 30, 2024 S356867
H2415522Certificate of AnalysisApr 30, 2024 S356867
H2415523Certificate of AnalysisApr 30, 2024 S356867
H2415524Certificate of AnalysisApr 30, 2024 S356867
H2415525Certificate of AnalysisApr 30, 2024 S356867

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Chemical and Physical Properties

SolubilitySoluble in DMSO: 22 mg/mL

Safety and Hazards(GHS)

WGK Germany 3
RIDADR NONHforallmodesoftransport

Related Documents

References

1. Penning TD, Chandrakumar NS, Chen BB, Chen HY, Desai BN, Djuric SW, Docter SH, Gasiecki AF, Haack RA, Miyashiro JM et al..  (2000)  Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase..  J Med Chem,  43  (4): (721-35).  [PMID:10691697]

Solution Calculators