SC-26196 - ≥98%, high purity , CAS No.218136-59-5

Item Number

S276482

Grouped product items
SKU	Size	Availability	Price
S276482-5mg	5mg	In stock	$124.90
S276482-10mg	10mg	In stock	$179.90
S276482-25mg	25mg	In stock	$405.90
S276482-50mg	50mg	In stock	$767.90

A\xa0selective Δ6 desaturase inhibitor

Basic Description

Synonyms	2,2-Diphenyl-5-[4-[(E)-pyridin-3-ylmethylideneamino]piperazin-1-yl]pentanenitrile；a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Selective Δ6 desaturase inhibitor (IC 50 =0.2 μM in vitro ). It displays selectivity over Δ5 and Δ9 desaturases (IC 50 values are >200 μM in vitro). Exhibits anti inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lin
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product description： SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties. Application： SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase: in mouse inner medullary collecting duct (IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) component in hepatic HepG2 cells in glioblastoma cell lines to test its effect post-radiation treatments

Names and Identifiers

IUPAC Name	2,2-diphenyl-5-[4-[(E)-pyridin-3-ylmethylideneamino]piperazin-1-yl]pentanenitrile
INCHI	InChI=1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+
InChi Key	QFYKXKMYVYOUNJ-JBASAIQMSA-N
Canonical SMILES	C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4
Isomeric SMILES	C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)/N=C/C4=CN=CC=C4
PubChem CID	9845201
Molecular Weight	423.56

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4 results found

Lot Number	Certificate Type	Date	Item
K2219127	Certificate of Analysis	Sep 20, 2023	S276482
K2219126	Certificate of Analysis	Sep 15, 2023	S276482
K2219128	Certificate of Analysis	Sep 15, 2023	S276482
K2219129	Certificate of Analysis	Sep 07, 2022	S276482

References

1. Obukowicz MG et al.. (1998) Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.. J Pharmacol Exp Ther, 287 (157-66). [PMID:9765335]
2. Hansen-Petrik MB et al.. (2002) Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.. Cancer Lett, 175 (2): (157-63). [PMID:11741743]

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Basic Description