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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S412391-5mg | 5mg | In stock | $246.90 | |
S412391-10mg | 10mg | In stock | $345.90 | |
S412391-25mg | 25mg | In stock | $642.90 | |
S412391-50mg | 50mg | In stock | $1,157.90 |
STAT3 Selective Inhibitors | Activators
Synonyms | SC-43|1400989-25-4|OT4AQX5MLU|SC 43|1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(4-cyanophenoxy)phenyl)urea|1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea|3-[4-chloro-3-(trifluoromethyl)phenyl]-1-[3-(4-cyanophenoxy)phenyl]urea|N-( |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | Information SC-43, a sorafenib derivative, is an agonist ofSrc-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6)and reduces liver fibrosis. SC-43 reducesp-STAT3and inducesapoptosiswith anti-tumor activity. Targets SHP-1 ; STAT3 |
ALogP | 5.568 |
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HBD Count | 2 |
Rotatable Bond | 5 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea |
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INCHI | InChI=1S/C21H13ClF3N3O2/c22-19-9-6-15(11-18(19)21(23,24)25)28-20(29)27-14-2-1-3-17(10-14)30-16-7-4-13(12-26)5-8-16/h1-11H,(H2,27,28,29) |
InChi Key | QIBWSQJZKMUZAK-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC(=C1)OC2=CC=C(C=C2)C#N)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F |
Isomeric SMILES | C1=CC(=CC(=C1)OC2=CC=C(C=C2)C#N)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F |
PubChem CID | 70688629 |
Molecular Weight | 431.8 |
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Lot Number | Certificate Type | Date | Item |
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K2210062 | Certificate of Analysis | Jul 18, 2022 | S412391 |
K2210063 | Certificate of Analysis | Jul 18, 2022 | S412391 |
K2210064 | Certificate of Analysis | Jul 18, 2022 | S412391 |
K2210065 | Certificate of Analysis | Jul 18, 2022 | S412391 |
Solubility | Solubility (25°C) In vitro DMSO: 86 mg/mL (199.16 mM); Ethanol: 25 mg/mL (57.89 mM); Water: Insoluble; |
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DMSO(mg / mL) Max Solubility | 86 |
DMSO(mM) Max Solubility | 199.166280685503 |
Water(mg / mL) Max Solubility | <1 |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |