SC-514 - 10mM in DMSO, high purity , CAS No.354812-17-2

Item Number

S423589

• Synonyms: SC-514|354812-17-2|4-Amino-[2,3'-bithiophene]-5-carboxamide|Sc 514|SC514|3-amino-5-thiophen-3-ylthiophene-2-carboxamide|3-amino-5-(3-thienyl)thiophene-2-carboxamide|3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide|GK 01140|CHEMBL193093|3-amino-5-(3-thioph
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: SC-514 is a selective and reversible inhibitor of IKKβ (IKK-2) (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. This compound attenuates NF-κB-induced gene expression of IL-6, IL-8 and Cox-2 (IC5
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
A selective and reversible inhibitor of IKKβ (IKK-2)