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SC-66 - 10mM in DMSO, high purity , CAS No.871361-88-5

10mM in DMSO

CAS#: 871361-88-5
Formula: C₁₈H₁₆N₂O
Molecular Weight: 276.34
PubChem CID: 6018993

Item Number

S426584

Grouped product items
SKU	Size	Availability	Price	Qty
S426584-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$72.90

Allosteric Akt inhibitor

Basic Description

Synonyms	(2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Biological description': "Allosteric Akt inhibitor. Interferes with PIP3 binding to Akt's PH domain. Additionally facilitates Akt ubiquitination. Displays anticancer activity in vitro and in vivo.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets

DDIT3 Tbio DDIT3 upstream open reading frame protein 0 Activities

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EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

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GMNN Tbio Geminin 0 Activities

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PTH1R Tclin Parathyroid hormone/parathyroid hormone-related peptide receptor 0 Activities

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POLH Tchem DNA polymerase eta 0 Activities

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RORC Tchem Nuclear receptor ROR-gamma 0 Activities

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

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VDR Tclin Vitamin D3 receptor 0 Activities

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HSP90AA1 Tchem Heat shock protein HSP 90-alpha 0 Activities

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TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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SMN1 Tchem Survival motor neuron protein 0 Activities

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WRN Tbio Werner syndrome ATP-dependent helicase 0 Activities

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities

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POLI Tchem DNA polymerase iota 0 Activities

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PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities

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RAB9A Tbio Ras-related protein Rab-9A 0 Activities

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BRCA1 Tchem Breast cancer type 1 susceptibility protein 0 Activities

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ATXN2 Tbio Ataxin-2 0 Activities

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XBP1 Tchem X-box-binding protein 1 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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APOBEC3G Tchem DNA dC->dU-editing enzyme APOBEC-3G 0 Activities

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TPR Tbio Nucleoprotein TPR 0 Activities

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TARDBP Tchem TAR DNA-binding protein 43 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

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HTT Tchem Huntingtin 0 Activities

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GSR Tclin Glutathione reductase, mitochondrial 0 Activities

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CGA Tbio Glycoprotein hormones alpha chain 0 Activities

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic 0 Activities

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NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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NPC1 Tchem NPC intracellular cholesterol transporter 1 0 Activities

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Names and Identifiers

IUPAC Name	(2E,6E)-2,6-bis(pyridin-4-ylmethylidene)cyclohexan-1-one
INCHI	InChI=1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
InChi Key	CYVVJSKZRBZHAV-UNZYHPAISA-N
Canonical SMILES	C1CC(=CC2=CC=NC=C2)C(=O)C(=CC3=CC=NC=C3)C1
Isomeric SMILES	C1C/C(=C\C2=CC=NC=C2)/C(=O)/C(=C/C3=CC=NC=C3)/C1
PubChem CID	6018993
Molecular Weight	276.34

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