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Senicapoc - ≥98%, high purity , Intermediate conductance calcium-activated potassium channel protein 4 blocker, CAS No.289656-45-7, Intermediate conductance calcium-activated potassium channel protein 4 blocker

Moligand™
≥98%

CAS#: 289656-45-7
Formula: C₂₀H₁₅F₂NO
Molecular Weight: 323.35
PubChem CID: 216327

Item Number

S125457

Grouped product items
SKU	Size	Availability	Price
S125457-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$105.90
S125457-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$212.90
S125457-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$284.90

View related series

KCa3.1 Channel blocker

Basic Description

Synonyms	Senicapoc\|289656-45-7\|2,2-bis(4-fluorophenyl)-2-phenylacetamide\|ICA-17043\|Senicapoc (USAN)\|Senicapoc [USAN]\|MFCD09027349\|TS6G201A6Q\|Benzeneacetamide, 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-\|PF-05416266\|C20H15F2NO\|Bis(4-fluorophenyl)phenylacetamide\|S
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	BLOCKER, CHANNEL BLOCKER
Mechanism of action	Intermediate conductance calcium-activated potassium channel protein 4 blocker
Note	卖完停产，不再备货
Product Description	Senicapoc(ICA17043) is a potent and selective Gardos channel blocker; blocked Ca(2+)-induced rubidium flux from human RBCs/ inhibited RBC dehydration with IC50s of 11 nM/30 nM, respectively.

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN2A Tclin Sodium channel protein type 2 subunit alpha 0 Activities

Discover Target: SCN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN3A Tclin Sodium channel protein type 3 subunit alpha 0 Activities

Discover Target: SCN3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN9A Tclin Sodium channel protein type 9 subunit alpha 0 Activities

Discover Target: SCN9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN4A Tclin Sodium channel protein type 4 subunit alpha 0 Activities

Discover Target: SCN4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN1A Tclin Sodium channel protein type 1 subunit alpha 0 Activities

Discover Target: SCN1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCN8A Tclin Sodium channel protein type 8 subunit alpha 0 Activities

Discover Target: SCN8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IK Tbio Protein Red 0 Activities

Discover Target: IK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 3 Activities

Discover Target: KCNN4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 0 Activities

Discover Target: KCNQ1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNA5 Tclin Potassium voltage-gated channel subfamily A member 5 0 Activities

Discover Target: KCNA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2,2-bis(4-fluorophenyl)-2-phenylacetamide
INCHI	InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChi Key	SCTZUZTYRMOMKT-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
Isomeric SMILES	C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
PubChem CID	216327
Molecular Weight	323.35

PubChem CID

ChEMBL Ligand

Wikipedia

CAS Registry No.

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1 results found

Lot Number	Certificate Type	Date	Item
K1503058	Certificate of Analysis	May 10, 2023	S125457

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