SGC707 - 97%, high purity , CAS No.1687736-54-4, Allosteric modulator of protein arginine methyltransferase 3

Item Number

S413846

• Synonyms: Tubastatin A BASE；1-(isoquinolin-6-yl)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)urea；
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase\u20053 (PRMT3) with IC50 and K_d of 31 nM and 53 nM, respectively.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of protein arginine methyltransferase 3

Product Description

Information

SGC707 SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 ( PRMT3 ) with IC50 and K d of 31 nM and 53 nM, respectively.

Targets

PRMT3 ; PRMT3 31 nM; 53 nM(Kd)

In vitro

In cells, SGC707 binds to PRMT3 and reduces PRMT3-dependent H4R3me2a. SGC707 also stabilizes PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.

In vivo

In CD-1 male mice, SGC707 (30 mg/kg, i.p.) gives good plasma exposure over 6 h with the peak plasma level of 38000 nM, which suggests that SGC707 is suitable for animal studies.

Cell Research(from reference)

Cell lines：293, LnCap, U2O s, HFF, MCF-7, and MDA-MB-231 cells 

Concentrations：100 μM 

Incubation Time：72 h