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SH-4-54 - 97%, high purity , CAS No.1456632-40-8
STAT3 Selective Inhibitors | Activators
Basic Description Specifications & Purity ≥97% Biochemical and Physiological Mechanisms SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description
Information
SH-4-54 is a potentSTATinhibitor withKDof 300 nM and 464 nM for STAT3 and STAT5, respectively.
Targets
STAT3 (Cell-free assay); STAT5 (Cell-free assay) 300 nM(Kd); 464 nM(Kd)
In vitro
SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets.
In vivo
In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3.
Cell Research(from reference)
Cell lines：BTSC lines 25M, 67EF, 73EF, 84EF and 127EF
Concentrations：~25 μM
Incubation Time：72 hours
Product Properties ALogP 6.221 Rotatable Bond 9
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References The page will load shortly, Thanks for your patience!
Names and Identifiers Pubchem Sid 488202308 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202308 IUPAC Name 4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid INCHI InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39) InChi Key VFPYGNNOSJWBHF-UHFFFAOYSA-N Canonical SMILES CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F Isomeric SMILES CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F PubChem CID 72188643 Molecular Weight 610.59
Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 100 mg/mL (163.77 mM); Ethanol: 50 mg/mL warmed with 50ºC Water: bath (81.88 mM); Water: Insoluble; DMSO(mg / mL) Max Solubility 100 DMSO(mM) Max Solubility 163.7760199 Water(mg / mL) Max Solubility ＜1 Molecular Weight 610.600 g/mol XLogP3 6.200 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 11 Rotatable Bond Count 9 Exact Mass 610.156 Da Monoisotopic Mass 610.156 Da Topological Polar Surface Area 103.000 Ų Heavy Atom Count 42 Formal Charge 0 Complexity 1010.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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C2321477
