SH-4-54 - 97%, high purity , CAS No.1456632-40-8

Item Number

S413742

• Specifications & Purity: ≥97%
• Biochemical and Physiological Mechanisms: SH-4-54 is a potent STAT inhibitor with K_D of 300 nM and 464 nM for STAT3 and STAT5, respectively.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

SH-4-54 is a potentSTATinhibitor withKDof 300 nM and 464 nM for STAT3 and STAT5, respectively.

Targets

STAT3 (Cell-free assay); STAT5 (Cell-free assay) 300 nM(Kd); 464 nM(Kd)

In vitro

SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets.

In vivo

In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3.

Cell Research(from reference)

Cell lines：BTSC lines 25M, 67EF, 73EF, 84EF and 127EF 

Concentrations：~25 μM 

Incubation Time：72 hours