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SH-4-54 - 97%, high purity , CAS No.1456632-40-8

  • ≥97%
Item Number
S413742
Grouped product items
SKUSizeAvailabilityPrice Qty
S413742-5mg
5mg
3
$122.90
S413742-25mg
25mg
2
$395.90
S413742-50mg
50mg
1
$632.90
S413742-100mg
100mg
1
$1,012.90

STAT3 Selective Inhibitors | Activators

Basic Description

Specifications & Purity≥97%
Biochemical and Physiological MechanismsSH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

SH-4-54 is a potentSTATinhibitor withKDof 300 nM and 464 nM for STAT3 and STAT5, respectively.


Targets

STAT3 (Cell-free assay); STAT5 (Cell-free assay) 300 nM(Kd); 464 nM(Kd)


In vitro

SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets.


In vivo

In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3.


Cell Research(from reference)

Cell lines:BTSC lines 25M, 67EF, 73EF, 84EF and 127EF 

Concentrations:~25 μM 

Incubation Time:72 hours 

AI Insight

Product Properties

ALogP6.221
Rotatable Bond9

Mechanisms of Action

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Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488202308
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488202308
IUPAC Name 4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid
INCHI InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39)
InChi Key VFPYGNNOSJWBHF-UHFFFAOYSA-N
Canonical SMILES CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
Isomeric SMILES CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC=C(C=C3)C(=O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F
PubChem CID 72188643
Molecular Weight 610.59

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
C2321477Certificate of AnalysisFeb 02, 2023 S413742
C2321478Certificate of AnalysisFeb 02, 2023 S413742
C2321481Certificate of AnalysisFeb 02, 2023 S413742
C2321492Certificate of AnalysisFeb 02, 2023 S413742
C2321493Certificate of AnalysisFeb 02, 2023 S413742
C2321497Certificate of AnalysisFeb 02, 2023 S413742
C2321552Certificate of AnalysisFeb 02, 2023 S413742
C2321572Certificate of AnalysisFeb 02, 2023 S413742

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 100 mg/mL (163.77 mM); Ethanol: 50 mg/mL warmed with 50ºC Water: bath (81.88 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility100
DMSO(mM) Max Solubility163.7760199
Water(mg / mL) Max Solubility<1
Molecular Weight610.600 g/mol
XLogP36.200
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Exact Mass610.156 Da
Monoisotopic Mass610.156 Da
Topological Polar Surface Area103.000 Ų
Heavy Atom Count42
Formal Charge0
Complexity1010.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1

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