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Home Cardiovascular Heart Autophagy SIB 1893 - 98%, high purity , CAS No.6266-99-5, Allosteric modulator of mGlu 4 receptor;Allosteric modulator of mGlu 5 receptor
SIB 1893 - 98%, high purity , CAS No.6266-99-5, Allosteric modulator of mGlu 4 receptor;Allosteric modulator of mGlu 5 receptor
mGlu5antagonist; also positive allosteric modulator at mGlu4receptors
Basic Description Synonyms SIB 1893|SIB-1893|2-methyl-6-(2-phenylethenyl)pyridine|6266-99-5|7370-21-0|(E)-2-methyl-6-styrylpyridine|SIB1893|2-methyl-6-[(E)-2-phenylethenyl]pyridine|(E/Z)-SIB-1893|[E]-2-Methyl-6-[2-phenylethenyl]pyridine|trans-6-Styryl-2-picoline|CHEMBL88612|MLS0026 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms A highly selective non-competitive antagonist for the metabotropic glutamate mGlu5receptor subtype; displays an IC50value of 0.3μM at hmGlu5, compared with > 100μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7and hmGlu8. Centrally active upon systemic administration Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of mGlu 4 receptor;Allosteric modulator of mGlu 5 receptor
Names and Identifiers IUPAC Name 2-methyl-6-[(E)-2-phenylethenyl]pyridine INCHI InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+ InChi Key SISOFUCTXZKSOQ-ZHACJKMWSA-N Canonical SMILES CC1=NC(=CC=C1)C=CC2=CC=CC=C2 Isomeric SMILES CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2 Alternate CAS 6266-99-5,7370-21-0 PubChem CID 5311432 NSC Number 36665 MeSH Entry Terms (E)-2-methyl-6-(2-phenylethenyl)pyridine;SIB 1893;SIB-1893;SIB1893 Molecular Weight 195.26
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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