Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Information
Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor ofPhosphodiesterase 5.
Targets
PDE5
In vivo
Chronic sildenafil treatment increases the detumescence phase in young and aged rats (p<0.05), although aged rats show a greater increase than young rats. Baseline cavernous PDE5 expression and activity are greater in aged vs young rats (p<0.05). After chronic sildenafil treatment cavernous PDE5 expression is increased in young (p<0.05) but not in aged rats. Chronic and acute sildenafil treatment similarly inhibits PDE5 activity in the penis of young and aged rats (p<0.05), coincident with its free plasma concentrations equivalent to clinically therapeutic ranges.