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Sildenafil Mesylate - 98%, high purity , CAS No.1308285-21-3

  • ≥98%
Item Number
S413169
Grouped product items
SKUSizeAvailabilityPrice Qty
S413169-100mg
100mg
In stock
$195.90
S413169-250mg
250mg
In stock
$202.90
S413169-500mg
500mg
In stock
$302.90
S413169-1g
1g
In stock
$549.90
S413169-5g
5g
In stock
$2,059.90

PDE5 Selective Inhibitors

Basic Description

Specifications & Purity≥98%
Biochemical and Physiological MechanismsSildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor ofPhosphodiesterase 5.


Targets

PDE5


In vivo

Chronic sildenafil treatment increases the detumescence phase in young and aged rats (p<0.05), although aged rats show a greater increase than young rats. Baseline cavernous PDE5 expression and activity are greater in aged vs young rats (p<0.05). After chronic sildenafil treatment cavernous PDE5 expression is increased in young (p<0.05) but not in aged rats. Chronic and acute sildenafil treatment similarly inhibits PDE5 activity in the penis of young and aged rats (p<0.05), coincident with its free plasma concentrations equivalent to clinically therapeutic ranges.

Product Properties

ALogP1.833
HBD Count1
Rotatable Bond7

Names and Identifiers

IUPAC Name 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one;methanesulfonic acid
INCHI InChI=1S/C22H30N6O4S.CH4O3S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;1-5(2,3)4/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);1H3,(H,2,3,4)
InChi Key WEWNUXJEVSROFW-UHFFFAOYSA-N
Canonical SMILES CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.CS(=O)(=O)O
PubChem CID 135425271
Molecular Weight 474.58(free base)

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
I2216438Certificate of AnalysisJul 11, 2022 S413169
I2216461Certificate of AnalysisJul 11, 2022 S413169
I2216462Certificate of AnalysisJul 11, 2022 S413169
I2216531Certificate of AnalysisJul 11, 2022 S413169
I2216614Certificate of AnalysisJul 11, 2022 S413169

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 100 mg/mL Water: 100 mg/mL Ethanol: 4 mg/mL
DMSO(mg / mL) Max Solubility100
DMSO(mM) Max Solubility211
Water(mg / mL) Max Solubility100

Related Documents

Solution Calculators