Sildenafil Mesylate - 10mM in DMSO, high purity , CAS No.1308285-21-3

Item Number

S421198

Grouped product items
SKU	Size	Availability	Price	Qty
S421198-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90

PDE5 Selective Inhibitors

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor ofPhosphodiesterase 5. Targets PDE5 In vivo Chronic sildenafil treatment increases the detumescence phase in young and aged rats (p<0.05), although aged rats show a greater increase than young rats. Baseline cavernous PDE5 expression and activity are greater in aged vs young rats (p<0.05). After chronic sildenafil treatment cavernous PDE5 expression is increased in young (p<0.05) but not in aged rats. Chronic and acute sildenafil treatment similarly inhibits PDE5 activity in the penis of young and aged rats (p<0.05), coincident with its free plasma concentrations equivalent to clinically therapeutic ranges.

ALogP

1.833

HBD Count

Rotatable Bond

Names and Identifiers

IUPAC Name	5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one;methanesulfonic acid
INCHI	InChI=1S/C22H30N6O4S.CH4O3S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;1-5(2,3)4/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);1H3,(H,2,3,4)
InChi Key	WEWNUXJEVSROFW-UHFFFAOYSA-N
Canonical SMILES	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.CS(=O)(=O)O
PubChem CID	135425271
Molecular Weight	474.58(free base)

DMSO(mg / mL) Max Solubility

100

DMSO(mM) Max Solubility

211

Water(mg / mL) Max Solubility

100

Solution Calculators

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Basic Description