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Silymarin - 80%, high purity , CAS No.65666-07-1

5 Citations

≥80%

CAS#: 65666-07-1
Formula: C₂₅H₂₂O₁₀
Molecular Weight: 482.44
MDL number: MFCD01776359
PubChem CID: 5213

Item Number

S304299

Grouped product items
SKU	Size	Availability	Price
S304299-1g	1g	In stock	$14.90
S304299-5g	5g	In stock	$42.90
S304299-25g	25g	In stock	$145.90
S304299-100g	100g	In stock	$395.90
S304299-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,374.90

Estrogenic, antioxidant and apoptotic agent

Basic Description

Synonyms	SILYMARIN \| Silybin \| 65666-07-1 \| Legalon \| Silliver \| Silybine \| Flavobin Spofa \| (2R,3R)-3,5,7-trihydroxy-2-[(2R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one \| Silibin \| 142796-20-1 \| Silimarin \| 802918-57-6 \| 846
Specifications & Purity	80%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product Introduction Silymarin is a flavonoid lignan derived from milk thistle (silymarin) plants. Application Silymarin has been used in research: Its antiviral, antibacterial, antifungal activities and cytotoxicity in vitro Effects of silymarin on bladder contraction in a rat model of cyclophosphamide (CYP) - induced cystitis Its effect on fumonisin B1 induced liver poisoning in mice

Names and Identifiers

IUPAC Name	3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one
INCHI	InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
InChi Key	SEBFKMXJBCUCAI-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
Isomeric SMILES	COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
PubChem CID	5213
Molecular Weight	482.44

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
I2109499	Certificate of Analysis	Jul 10, 2024	S304299
I2109502	Certificate of Analysis	Jul 10, 2024	S304299
I2109505	Certificate of Analysis	Jul 10, 2024	S304299
A2429412	Certificate of Analysis	Aug 11, 2021	S304299
D2324152	Certificate of Analysis	Aug 11, 2021	S304299
D2328029	Certificate of Analysis	Aug 11, 2021	S304299
E2322596	Certificate of Analysis	Aug 11, 2021	S304299

Sensitivity

Light sensitive

Flash Point(°C)

274.4℃

Boil Point(°C)

793℃ at 760 mmHg

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.

Citations of This Product

1. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2024) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 238 (106450). [PMID:38143010]
2. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong. (2023) Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, (104351). [PMID:38135203]
3. Yuxu Chen, Zhiye Zhao, Shancheng Guo, Yaxian Li, Haiaolong Yin, Lei Tian, Guiguang Cheng, Ye Li. (2023) Red Rice Seed Coat Targeting SPHK2 Ameliorated Alcoholic Liver Disease via Restored Intestinal Barrier and Improved Gut Microbiota in Mice. Nutrients, 15 (19): (4176). [PMID:37836459]
4. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan. (2023) Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway. FISH PHYSIOLOGY AND BIOCHEMISTRY, (1-16). [PMID:37542703]
5. Qiang-Ming Li, Xiu-Rong Yang, Xue-Qiang Zha, Li-Hua Pan, Dan-Dan Zang, Feng-Yun Zhang, Jian-Ping Luo. (2022) Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways. CHEMISTRY & BIODIVERSITY, 19 (8): (e202200471). [PMID:35774029]

References

1. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2024) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 238 (106450). [PMID:38143010]
2. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong. (2023) Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, (104351). [PMID:38135203]
3. Yuxu Chen, Zhiye Zhao, Shancheng Guo, Yaxian Li, Haiaolong Yin, Lei Tian, Guiguang Cheng, Ye Li. (2023) Red Rice Seed Coat Targeting SPHK2 Ameliorated Alcoholic Liver Disease via Restored Intestinal Barrier and Improved Gut Microbiota in Mice. Nutrients, 15 (19): (4176). [PMID:37836459]
4. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan. (2023) Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway. FISH PHYSIOLOGY AND BIOCHEMISTRY, (1-16). [PMID:37542703]
5. Qiang-Ming Li, Xiu-Rong Yang, Xue-Qiang Zha, Li-Hua Pan, Dan-Dan Zang, Feng-Yun Zhang, Jian-Ping Luo. (2022) Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways. CHEMISTRY & BIODIVERSITY, 19 (8): (e202200471). [PMID:35774029]

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