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SJ10542 - 99%, high purity , CAS No.S658806

Item Number

S658806

Grouped product items
SKU	Size	Availability	Price	Qty
S658806-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90

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Basic Description

Specifications & Purity	99%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Product Description	SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC 50 s of 14, 11, and 24 nM for JAK2 , JAK3 , and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter. Appearance:Solid IC50& Target:JAK2 14 nM (DC 50 ) JAK3 11 nM (DC 50 ) JAK2-fusion ALL 24 nM (DC 50 ) Cereblon Biological Activity:SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC 50 s of 14, 11, and 24 nM for JAK2 , JAK3 , and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter.

Canonical SMILES	O=C(C1=CC=C(NC2=NC(NC=C3)=C3C(C4=CN(C5(CN(S(=O)(CC)=O)C5)CC#N)N=C4)=N2)C=C1)NCCCN(CC6)CCN6C7=CC=C(C=C7)C8C(NC(CC8)=O)=O
Molecular Weight	818.95

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Solubility	DMSO : 46.67 mg/mL (56.99 mM; Need ultrasonic)

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