| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S655408-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $604.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC 50 of 7.16 nM, but is far less effective at degrading p38δ (DC 50 =299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM IC50& Target:p38α 7.16 nM (DC 50 ) p38δ 299 nM (DC 50 ) VHL |
| Canonical SMILES | FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1 |
|---|---|
| Molecular Weight | 1120.27 |
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