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SKA 121 - ≥98%(HPLC), high purity , CAS No.1820708-73-3, Activator of K Ca3.1

  • Moligand™
  • ≥98%(HPLC)
Item Number
S287446
Grouped product items
SKUSizeAvailabilityPrice Qty
S287446-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$78.90
S287446-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$147.90
S287446-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$335.90
S287446-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$602.90
S287446-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,088.90
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Positive allosteric modulator of KCa3.1 (IK) channels

View related series
KCa3.1 Activator

Basic Description

Synonyms5-Methylnaphth[2,1-d]oxazol-2-amine；SKA-121；5-Methylnaphth[2,1-d]oxazol-2-amine, 5-Methylnaphtho[2,1-d]oxazol-2-amine；SKA121；5-methyl-naphth[2,1-d]oxazol-2-amine
Specifications & Purity≥98%(HPLC)
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR
Mechanism of actionActivator of K Ca3.1
Product Description

Product description：

SKA-121 is a selective KCa3.1 activator. SKA-121 exhibits EC50s of 109 nM and 4.4 μM for KCa3.1 and KCa2.3, respectively.


Associated Targets

KCNN4 Tchem Intermediate conductance calcium-activated potassium channel protein 4 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-methylbenzo[g][1,3]benzoxazol-2-amine
INCHI InChI=1S/C12H10N2O/c1-7-6-10-11(15-12(13)14-10)9-5-3-2-4-8(7)9/h2-6H,1H3,(H2,13,14)
InChi Key JEGUERWMMMQFJV-UHFFFAOYSA-N
Canonical SMILES CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N
Isomeric SMILES CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N
PubChem CID 91827362
MeSH Entry Terms 5-methylnaphtho(2,1-d)oxazol-2-amine;SKA-121
Molecular Weight 198.23

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 19.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.91, Max Conc. mM: 50

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

 SDS

 Specification Sheet

References

1. Coleman N, Brown BM, Oliván-Viguera A, Singh V, Olmstead MM, Valero MS, Köhler R, Wulff H.  (2014)  New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1..  Mol Pharmacol,  86  (3): (342-57).  [PMID:24958817]

Solution Calculators

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