SKA-31 - 97%, high purity , CAS No.40172-65-4, Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1

Item Number

N135127

• Synonyms: 40172-65-4|Naphtho[1,2-d]thiazol-2-amine|SKA-31|2-Amino-beta-naphthothiazole|Naphtho[1,2-d]thiazol-2-ylamine|SKA 31|2-Aminonaphthiazole|naphtho[1,2-d][1,3]thiazol-2-amine|benzo[e][1,3]benzothiazol-2-amine|2-Aminonaphtho(1,2-d)thiazole|2-Aminonaphtho[1,2-d
• Specifications & Purity: Moligand™, ≥97%
• Biochemical and Physiological Mechanisms: SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in exper
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ACTIVATOR
• Mechanism of action: Activator of K Ca2.1;Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure