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SKF-83566 , CAS No.S613610, Inhibitor of adenylyl cyclase 2;Antagonist of D 1 receptor;Antagonist of D 5 receptor

Moligand™

PubChem CID: 1243

Item Number

S613610

Grouped product items
SKU	Size	Availability	Price	Qty
S613610-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
S613610-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

adenylyl cyclase 2 Inhibitor D1 receptor Antagonist D5 receptor Antagonist

Basic Description

Synonyms	99295-33-7\|SKF-83566\|SK&F-83566\|Skf 83566\|8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol\|SK&F 83566\|1H-3-Benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-\|D203LR7XUS\|SK-83566\|CHEMBL324017\|8-bromo-3-methyl-5-phenyl-1,2,4,5
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST, INHIBITOR
Mechanism of action	Inhibitor of adenylyl cyclase 2;Antagonist of D 1 receptor;Antagonist of D 5 receptor

Associated Targets

DRD1 Tclin D(1A) dopamine receptor 2 Activities

Discover Target: DRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin D(2) dopamine receptor 0 Activities

Discover Target: DRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD5 Tchem D(1B) dopamine receptor 4 Activities

Discover Target: DRD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADCY3 Tbio Adenylate cyclase type 3 0 Activities

Discover Target: ADCY3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADCY1 Tchem Adenylate cyclase type 1 0 Activities

Discover Target: ADCY1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADCY2 Tchem Adenylate cyclase type 2 0 Activities

Discover Target: ADCY2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7-bromo-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
INCHI	InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
InChi Key	XFTVOHWWEQGXLS-UHFFFAOYSA-N
Canonical SMILES	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O
Isomeric SMILES	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Br
PubChem CID	1243

PubChem CID

ChEMBL Ligand

BindingDB Ligand

GPCRdb Ligand

References

1. Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH, Niznik HB. (1991) Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.. Nature, 350 (6319): (614-9). [PMID:1826762]
2. Bakthavachalam V, Baindur N, Madras BK, Neumeyer JL. (1991) Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands.. J Med Chem, 34 (11): (3235-41). [PMID:1956042]
3. Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ. (2013) Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.. J Pharmacol Exp Ther, 347 (2): (276-87). [PMID:24008337]

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