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SL-327 - 98%(total of isomer), high purity , CAS No.305350-87-2, Inhibitor of mitogen-activated protein kinase kinase 2

  • Moligand™
  • ≥98%
  • mixture of isomers
Item Number
S125929
Grouped product items
SKUSizeAvailabilityPrice Qty
S125929-10mg
10mg
In stock
$116.90
S125929-50mg
50mg
In stock
$391.90
S125929-250mg
250mg
In stock
$1,764.90

MEK inhibitor

Basic Description

SynonymsSL327|305350-87-2|SL-327|MEK1/2 Inhibitor|SL 327|3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile|(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile|alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluo
Specifications & Purity98%(total of isomer)
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of mitogen-activated protein kinase kinase 2
Product Description

SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively.


Associated Targets

MAP2K2 Tclin Dual specificity mitogen-activated protein kinase kinase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
INCHI InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChi Key JLOXTZFYJNCPIS-FYWRMAATSA-N
Canonical SMILES C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
Isomeric SMILES C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F
WGK Germany 3
PubChem CID 9549284
Molecular Weight 335.35

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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6 results found

Lot NumberCertificate TypeDateItem
F2316495Certificate of AnalysisMay 18, 2023 S125929
F2316840Certificate of AnalysisMay 18, 2023 S125929
F2316849Certificate of AnalysisMay 18, 2023 S125929
F2316850Certificate of AnalysisMay 18, 2023 S125929
F2316854Certificate of AnalysisMay 18, 2023 S125929
F2316857Certificate of AnalysisMay 18, 2023 S125929

Chemical and Physical Properties

SolubilityDMSO 4 mg/mL Water <1 mg/mL Ethanol 7 mg/mL
SensitivityLight Sensitive,Air Sensitive,Moisture Sensitive,Heat Sensitive
Melt Point(°C)128 °C

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

References

1. Lindgren HS et al..  (2009)  Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease..  Neuropsychopharmacology,  34  (12): (2477-88).  [PMID:19606087]
2. Li X & Wolf ME.  (2011)  Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens..  Eur J Neurosci,  34  (2): (190-8).  [PMID:21692887]
3. Almela P et al..  (2009)  Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart..  J Pharmacol Exp Ther,  330  (3): (771-82).  [PMID:19567779]
4. Knapp DJ et al..  (2011)  Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety..  Brain Behav Immun,  25 Suppl 1  (S146-54).  [PMID:21377524]
5. Groblewski PA et al..  (2011)  Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice..  Behav Brain Res,  217  (2): (399-407).  [PMID:21074569]
6. Martín F et al..  (2011)  Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal..  Br J Pharmacol,  163  (4): (857-75).  [PMID:21615389]
7. Almela P et al..  (2008)  The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts..  Br J Pharmacol,  155  (73-83).  [PMID:18536752]

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