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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S125929-10mg | 10mg | In stock | $116.90 | |
S125929-50mg | 50mg | In stock | $391.90 | |
S125929-250mg | 250mg | In stock | $1,764.90 |
MEK inhibitor
Synonyms | SL327|305350-87-2|SL-327|MEK1/2 Inhibitor|SL 327|3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile|(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile|alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluo |
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Specifications & Purity | 98%(total of isomer) |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of mitogen-activated protein kinase kinase 2 |
Product Description | SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile |
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INCHI | InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+ |
InChi Key | JLOXTZFYJNCPIS-FYWRMAATSA-N |
Canonical SMILES | C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F |
Isomeric SMILES | C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F |
WGK Germany | 3 |
PubChem CID | 9549284 |
Molecular Weight | 335.35 |
PubChem CID | 9549284 |
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ChEMBL Ligand | CHEMBL261237 |
CAS Registry No. | 305350-87-2 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F2316495 | Certificate of Analysis | May 18, 2023 | S125929 |
F2316840 | Certificate of Analysis | May 18, 2023 | S125929 |
F2316849 | Certificate of Analysis | May 18, 2023 | S125929 |
F2316850 | Certificate of Analysis | May 18, 2023 | S125929 |
F2316854 | Certificate of Analysis | May 18, 2023 | S125929 |
F2316857 | Certificate of Analysis | May 18, 2023 | S125929 |
Solubility | DMSO 4 mg/mL Water <1 mg/mL Ethanol 7 mg/mL |
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Sensitivity | Light Sensitive,Air Sensitive,Moisture Sensitive,Heat Sensitive |
Melt Point(°C) | 128 °C |
WGK Germany | 3 |
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1. Lindgren HS et al.. (2009) Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease.. Neuropsychopharmacology, 34 (12): (2477-88). [PMID:19606087] |
2. Li X & Wolf ME. (2011) Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens.. Eur J Neurosci, 34 (2): (190-8). [PMID:21692887] |
3. Almela P et al.. (2009) Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart.. J Pharmacol Exp Ther, 330 (3): (771-82). [PMID:19567779] |
4. Knapp DJ et al.. (2011) Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety.. Brain Behav Immun, 25 Suppl 1 (S146-54). [PMID:21377524] |
5. Groblewski PA et al.. (2011) Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice.. Behav Brain Res, 217 (2): (399-407). [PMID:21074569] |
6. Martín F et al.. (2011) Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal.. Br J Pharmacol, 163 (4): (857-75). [PMID:21615389] |
7. Almela P et al.. (2008) The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.. Br J Pharmacol, 155 (73-83). [PMID:18536752] |