SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with K d values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Product Description
SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with K d values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively
In Vitro
SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with K i values of <10 nM and displays a selectivity of >900-fold for cIAP1 over XIAP. SM-1295 (compound 5) exhibits an IC 50 of 46 nM in MDA-MB-231. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
