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SMER28 - >99%, high purity , CAS No.307538-42-7
Positive regulator of autophagy
Basic Description Synonyms SMER28|307538-42-7|SMER 28|N-Allyl-6-bromoquinazolin-4-amine|6-bromo-N-(prop-2-en-1-yl)quinazolin-4-amine|6-Bromo-N-2-propenyl-4-quinazolinamine|6-bromo-N-prop-2-enylquinazolin-4-amine|SMER-28|CHEMBL494325|4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-|6-bro Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53Tα-synuclein, associated with Huntington's and Parkin Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Product Description application：
SMER28 may be used in mTOR-mediated signaling studies.
Names and Identifiers IUPAC Name 6-bromo-N-prop-2-enylquinazolin-4-amine INCHI InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15) InChi Key BCPOLXUSCUFDGE-UHFFFAOYSA-N Canonical SMILES C=CCNC1=NC=NC2=C1C=C(C=C2)Br Isomeric SMILES C=CCNC1=NC=NC2=C1C=C(C=C2)Br WGK Germany 3 PubChem CID 1560402 Molecular Weight 264.12
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 26.41, Max Conc. mM: 100；DMSO: >20 mg/mL H2O: insoluble Sensitivity Light sensitive
Safety and Hazards(GHS) Pictogram(s) GHS05 , GHS07 Signal Danger Hazard Statements H315: Causes skin irritation
H335: May cause respiratory irritation
H318: Causes serious eye damage
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
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