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SNS-314 Mesylate - 10mM in DMSO, high purity , CAS No.1146618-41-8
Potent pan-Aurora kinase inhibitor
Basic Description Synonyms SNS-314 Mesylate|1146618-41-8|SNS 314 mesylate|SNS-314 (mesylate)|KGW32FDY3U|1-(3-chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea;methanesulfonic acid|Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Potent, ATP-competitive Aurora kinase inhibitor (IC50values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits bothin vitroandin vivoactivity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative ef Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Names and Identifiers IUPAC Name 1-(3-chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea;methanesulfonic acid INCHI InChI=1S/C18H15ClN6OS2.CH4O3S/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16;1-5(2,3)4/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26);1H3,(H,2,3,4) InChi Key FYCODPVDEFFWSR-UHFFFAOYSA-N Canonical SMILES CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4 Isomeric SMILES CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4 PubChem CID 24995523 Molecular Weight 527.04
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