SNX-2112 (PF-04928473) - ≥98%, high purity , CAS No.908112-43-6

Item Number

S127510

Grouped product items
SKU	Size	Availability	Price
S127510-1mg	1mg	In stock	$65.90
S127510-5mg	5mg	In stock	$251.90
S127510-10mg	10mg	In stock	$345.90
S127510-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$906.90
S127510-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,631.90

Potent selective Hsp90 inhibitor

Basic Description

Synonyms	HMS3656P07 \| Q27461098 \| BCP0726000309 \| 4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide \| AKOS027270068 \| 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(((1r,4r)
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	SNX-2112 is a potent synthetic heat shock protein 90 inhibitor with an IC50 of 0.92 μM for K562 cells.Potent selective Hsp90 inhibitor.\xa0Binds to the ATP pocket of\xa0Hsp90 alpha\xa0and\xa0Hsp90 beta.\xa0Studies demonstates that SNX-2112 can exhibit
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

IUPAC Name	4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide
INCHI	InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)
InChi Key	ZFVRYNYOPQZKDG-UHFFFAOYSA-N
Canonical SMILES	CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
Isomeric SMILES	CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
PubChem CID	24772860
Molecular Weight	464.48

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
J2128068	Certificate of Analysis	Aug 01, 2023	S127510
J2128069	Certificate of Analysis	Aug 01, 2023	S127510
J2128070	Certificate of Analysis	Aug 01, 2023	S127510
J2128071	Certificate of Analysis	Aug 01, 2023	S127510
J2128075	Certificate of Analysis	Aug 01, 2023	S127510

Citations of This Product

1. Jingqi Li, Qi Zhang, Yutong Chen, Chengyu Lu, Yongbin Tong. (2023) Pharmacokinetics, Tissue Distribution and Excretion of Demethyleneberberine, a Metabolite of Berberine, in Rats and Mice. MOLECULES, 28 (23): (7725). [PMID:38067456] [10.3390/molecules28237725]

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Basic Description