Grouped product items

SKU

Size

Availability

Price

Qty

S115316-10g

10g

Available within 4-8 weeks(?)

$11.90

S115316-25g

25g

Available within 4-8 weeks(?)

$22.90

S115316-50g

50g

Available within 4-8 weeks(?)

$40.90

S115316-100g

100g

Available within 4-8 weeks(?)

$52.90

S115316-250g

250g

Available within 4-8 weeks(?)

$117.90

Basic Description

Synonyms	6018-19-5\|Sodium 4-aminosalicylate dihydrate\|Parasal sodium\|sodium 4-amino-2-hydroxybenzoate dihydrate\|Pamisyl sodium\|Sodium aminosalicylate\|AMINOSALICYLATE SODIUM\|TEEBACIN\|Nemasol sodium\|Paramisan sodium\|Sodium P.A.S.\|4-Aminosalicylic acid sodium salt di
Specifications & Purity	≥98%
Storage Temp	Argon charged
Shipped In	Normal
Action Type	INHIBITOR
Mechanism of action	Dihydrofolate reductase inhibitor

Associated Targets

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	sodium;4-amino-2-hydroxybenzoate;dihydrate
INCHI	InChI=1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1
InChi Key	GMUQJDAYXZXBOT-UHFFFAOYSA-M
Canonical SMILES	C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]
Isomeric SMILES	C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]
RTECS	VO1700000
Alternate CAS	133-10-8
PubChem CID	16211148
Molecular Weight	211.15
Reaxy-Rn	4166128

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot Number	Certificate Type	Date	Item
E1810030	Certificate of Analysis	Sep 12, 2022	S115316
B2315489	Certificate of Analysis	Jul 16, 2022	S115316
I2202817	Certificate of Analysis	Jul 16, 2022	S115316
I2202818	Certificate of Analysis	Jul 16, 2022	S115316
I2202819	Certificate of Analysis	Jul 16, 2022	S115316
I2202820	Certificate of Analysis	Jul 16, 2022	S115316
I2202821	Certificate of Analysis	Jul 16, 2022	S115316
I2202822	Certificate of Analysis	Jul 16, 2022	S115316

Chemical and Physical Properties

Sensitivity	light & air sensitive
Melt Point(°C)	250°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
RTECS	VO1700000
Reaxy-Rn	4166128

Alternative Products

References

1. Lan Hong,Wendy Jiang,Wei Zheng,Su Zeng. (2010-12-17) HPLC analysis of para-aminosalicylic acid and its metabolite in plasma, cerebrospinal fluid and brain tissues.. Journal of pharmaceutical and biomedical analysis, 54 ((5)): (1101-1109). [PMID:21159459]
2. Lan Hong,Wendy Jiang,Hao Pan,Yueming Jiang,Su Zeng,Wei Zheng. (2011-07-20) Brain regional pharmacokinetics of p-aminosalicylic acid and its N-acetylated metabolite: effectiveness in chelating brain manganese.. Drug metabolism and disposition: the biological fate of chemicals, 39 ((10)): (1904-1909). [PMID:21768272]
3. Chih-Cheng Lai,Che-Kim Tan,Yu-Tsung Huang,Chun-Hsing Liao,Po-Ren Hsueh. (2011-07-30) Fluoroquinolone-resistant tuberculosis at a medical centre in Taiwan, 2005-10.. The Journal of antimicrobial chemotherapy, 66 ((10)): (2437-2438). [PMID:21798881]
4. S M Vesenbeckh,J Becker,C Huhnt,B Karras,T T Bauer,H Mauch,H Rüssmann,N Schönfeld. (2011-08-13) Successful oral desensitization to i.v. para-aminosalicylic acid (PAS) using encapsulated PAS dry substance.. Infection, 40 ((2)): (199-202). [PMID:21833615]
5. Cezary Chojnacki,Ewa Walecka-Kapica,Grazyna Klupinska,Monika Pawłowicz,Antoni Florkowski,Patrycja Wachowska-Kelly,Jan Chojnacki. (2011-09-23) [Evaluation of the influence of tianeptine on the psychosomatic status of patients with ulcerative colitis in remission].. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31 ((182)): (92-96). [PMID:21936344]
6. S Thee,E W Zöllner,M Willemse,A C Hesseling,K Magdorf,H S Schaaf. (2011-09-29) Abnormal thyroid function tests in children on ethionamide treatment.. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 15 ((9)): (1191-1193). [PMID:21943844]
7. Amanda S Fivian-Hughes,Joanna Houghton,Elaine O Davis. (2011-10-29) Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.. Microbiology (Reading, England), 158 ((Pt 2)): (308-318). [PMID:22034487]
8. Fuqiang An,Ruikui Du,Xiaohua Wang,Min Wan,Xin Dai,Jianfeng Gao. (2011-12-16) Adsorption of phenolic compounds from aqueous solution using salicylic acid type adsorbent.. Journal of hazardous materials, 201-202 (74-81). [PMID:22169143]
9. A P Marreilha Dos Santos,Rui L Lucas,Vanda Andrade,M Luísa Mateus,Dejan Milatovic,Michael Aschner,M Camila Batoreu. (2011-12-20) Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.. Toxicology and applied pharmacology, 258 ((3)): (394-402). [PMID:22178737]
10. Wei-Ping Qin,Tian-Jia Liang,Yue-Ming Jiang. (2012-02-18) [A chronic moderate manganism poisoning treated with sodium p-aminosalicylic acid].. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 29 ((8)): (619-620). [PMID:22335167]
11. Gaurav Vadnerkar,Suneela Dhaneshwar. (2012-06-26) Macromolecular prodrug of 4-aminosalicylic acid for targeted delivery to inflamed colon.. Current drug discovery technologies, 10 ((1)): (16-24). [PMID:22725691]
12. Shadeed Gad,Lidia Tajber,Owen I Corrigan,Anne Marie Healy. (2012-08-14) Preparation and characterisation of novel spray-dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state.. The Journal of pharmacy and pharmacology, 64 ((9)): (1264-1274). [PMID:22881439]
13. Sumit Chakraborty,Todd Gruber,Clifton E Barry,Helena I Boshoff,Kyu Y Rhee. (2012-11-03) Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.. Science (New York, N.Y.), 339 ((6115)): (88-91). [PMID:23118010]
14. A C Liwa,H S Schaaf,B Rosenkranz,H I Seifart,A H Diacon,P R Donald. (2012-11-24) Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation.. Journal of tropical pediatrics, 59 ((2)): (90-94). [PMID:23174991]
15. Dinamene Santos,M Camila Batoreu,Michael Aschner,Ana P Marreilha dos Santos. (2013-01-15) Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity.. Biological trace element research, 152 ((1)): (113-116). [PMID:23315311]
16. Diana Couto,Daniela Ribeiro,Marisa Freitas,Ana Gomes,José L F C Lima,Eduarda Fernandes. (2011-01-07) Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine.. Redox report : communications in free radical research, 15 ((6)): (259-267). [PMID:21208525]
17. Kim S Sugamori,Debbie Brenneman,Denis M Grant. (2011-02-15) Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice.. Drug metabolism and disposition: the biological fate of chemicals, 39 ((5)): (882-890). [PMID:21317369]
18. . (2012-03-01) Drugs for inflammatory bowel disease.. Treatment guidelines from the Medical Letter, 10 ((115)): (19-28). [PMID:22361569]
19. Shuichi Yano,Kanako Kobayashi,Toshikazu Ikeda. (2012-05-19) Multidrug-resistant tuberculosis that required 2 years for diagnosis.. BMJ case reports, 2012 (doi:10-doi:10). [PMID:22605803]
20. Joo-Hee Kim,Seung Hun Jang,Dong Hoon Kim,Sunghoon Park,Dong-Gyu Kim,Ki-Suck Jung. (2013-01-29) A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110 ((2)): (118-119). [PMID:23352532]
21. J Furin,G Brigden,E Lessem,M C Becerra. (2013-07-06) Novel pediatric delivery systems for second-line anti-tuberculosis medications: a case study.. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 17 ((9)): (1239-1241). [PMID:23827936]

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Sodium 4-aminosalicylate dihydrate - 98%, high purity , Dihydrofolate reductase inhibitor, CAS No.6018-19-5, Dihydrofolate reductase inhibitor

Basic Description

Associated Targets

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
S115316-10g	10g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$11.90
S115316-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$22.90
S115316-50g	50g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$40.90
S115316-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$52.90
S115316-250g	250g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$117.90