Sodium cholate hydrate - for cell culture,≥99.0%, high purity , CAS No.206986-87-0

Item Number

S104206

• Synonyms: Sodium cholate hydrate|206986-87-0|Sodium cholate hydrate(1:1:1)|73163-53-8|sodium;(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
• Specifications & Purity: for cell culture, ≥99%
• Biochemical and Physiological Mechanisms: Reduction in 12-α hydroxylase activity leads to low levels of cholic acid in liver disease.
• Storage Temp: Argon charged
• Shipped In: Normal
• Grade: for cell culture

Product Description

Cholate is a primary bile acid produced from cholesterol in the liver. It is an anionic detergent synthesized from cholesterol in the presence of sterol 12α-hydroxylase (CYP8B1). 

Application：

Cholate is a bile acid produced in liver during cholesterol breakdown. Cholate downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis). Cholate, an anionic detergent, is used alone and in combination with urea to extract and reconstitute membrane proteins and protein complexes.
Sodium cholate hydrate has been used:
as a bile acid to induce bile acid-responsive (BEAR) transcription system,
as a component of Campylobacter defined broth (CDB) to test its effect on stress response in Campylobacter jejuni{52
to test its sensitivity towards the bile acid sensor;