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Sodium Dichloroacetate - >99.0%(T), high purity , CAS No.2156-56-1

≥99%(T)

CAS#: 2156-56-1
Formula: C₂HCl₂NaO₂
Molecular Weight: 150.92
Beilstein Registry Number: 2(2)194
PubChem CID: 517326

Item Number

S161233

Grouped product items
SKU	Size	Availability	Price
S161233-5g	5g	In stock	$41.90
S161233-25g	25g	In stock	$133.90
S161233-100g	100g	In stock	$411.90

Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor

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Salt

Basic Description

Synonyms	Sodium dichloroacetate\|2156-56-1\|sodium 2,2-dichloroacetate\|Dichloroacetic acid sodium salt\|Ceresine\|Dichloroacetate Sodium\|ACETIC ACID, DICHLORO-, SODIUM SALT\|Dca sodium\|CPC-211\|DCA\|Sodium dichloroacetate [USAN]\|Bichloroacetic Acid\|SodiumDichloroacetate-
Specifications & Purity	≥99%(T)
Biochemical and Physiological Mechanisms	Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulatio
Storage Temp	Room temperature,Argon charged
Shipped In	Normal
Product Description	Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity. Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.

Associated Targets

ROCK2 Tclin Rho-associated protein kinase 2 0 Activities

Discover Target: ROCK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDK1 Tchem [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 0 Activities

Discover Target: PDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDK3 Tchem [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 0 Activities

Discover Target: PDK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CISD1 Tchem CDGSH iron-sulfur domain-containing protein 1 0 Activities

Discover Target: CISD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	sodium;2,2-dichloroacetate
INCHI	InChI=1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1
InChi Key	LUPNKHXLFSSUGS-UHFFFAOYSA-M
Canonical SMILES	C(C(=O)[O-])(Cl)Cl.[Na+]
Isomeric SMILES	C(C(=O)[O-])(Cl)Cl.[Na+]
WGK Germany	2
RTECS	AG9275000
PubChem CID	517326
Molecular Weight	150.92
Beilstein	2(2)194
Reaxy-Rn	3916178

Certificates

Certificate of Analysis(COA)

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16 results found

Lot Number	Certificate Type	Date	Item
C2414747	Certificate of Analysis	Mar 04, 2024	S161233
C2414748	Certificate of Analysis	Mar 04, 2024	S161233
C2414749	Certificate of Analysis	Mar 04, 2024	S161233
C2328577	Certificate of Analysis	Feb 09, 2023	S161233
C2328591	Certificate of Analysis	Feb 09, 2023	S161233
C2328594	Certificate of Analysis	Feb 09, 2023	S161233
C2328595	Certificate of Analysis	Feb 09, 2023	S161233
C2328604	Certificate of Analysis	Feb 09, 2023	S161233
C2328605	Certificate of Analysis	Feb 09, 2023	S161233
H2331073	Certificate of Analysis	Feb 09, 2023	S161233
J2311097	Certificate of Analysis	Feb 09, 2023	S161233
L2326072	Certificate of Analysis	Feb 09, 2023	S161233
F23021203	Certificate of Analysis	Jul 27, 2022	S161233
J2227513	Certificate of Analysis	Jul 27, 2022	S161233
J2227524	Certificate of Analysis	Jul 27, 2022	S161233
J2227542	Certificate of Analysis	Jul 27, 2022	S161233

Solubility

Solvent:water, Max Conc. mg/mL: 15.09, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 15.09, Max Conc. mM: 100

Sensitivity

Moisture sensitive.

Melt Point(°C)

198 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H351:Suspected of causing cancer
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P281:Use personal protective equipment as required.
WGK Germany	2
RTECS	AG9275000
Reaxy-Rn	3916178

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