Basic Description

Specifications & Purity

Ph.Eur., NF, JP, EtOH-based

Shipped In

Normal

Grade

JP, NF, Ph.Eur.

Product Description

S494224, sodium starch glycolate, is a superdistintegrant made from potato starch by carboxymethylation and crosslinking for tablets and other oral solid dosage forms. Its unique combination of performance and cost-effectiveness has established as globally recognized and widely used product in the pharmaceutical industry.

S494224 demonstrates strong swelling properties upon contact with water and other media. This highly pure excipient retains its spheroid structure to promote good flow, contain little sodium chloride or ethanol, and have high brightness.

Benefits:

1.Good flowability and mixing properties

2.Specialty grades

3.Strong swelling properties

Product specifications and parameters:

SKU	pH Value	GMO Free	Compendial Type	Main Application	Pack Size
S494224-NM-500g	5.5 – 7.5	✓	A	Superdisintegrant with a rapid and high degree of swelling for tablet and capsule formulations. Especially for poorly water-soluble actives and tablet matrices with higher pH values.	500g
S494224-CLV-500g	5.5 – 7.5	✓	A	Special grade with increased number of crosslinkings. Especially suited for wet granulation applications.	500g
S494224-PCF-500g	5.5 – 7.5	✓	A	Special grade with max. 0.7 % NaCl recommended for APIs which require a very low ion content.	500g
S494224-Low pH-500g	5.5 – 7.5	✓	B	Special grade with low pH value. Complies with Type B of Ph. Eur, NF, JP.	500g
S494224-NM-2.5kg	5.5 – 7.5	✓	A	Superdisintegrant with a rapid and high degree of swelling for tablet and capsule formulations. Especially for poorly water-soluble actives and tablet matrices with higher pH values.	2.5kg
S494224-CLV-2.5kg	5.5 – 7.5	✓	A	Special grade with increased number of crosslinkings. Especially suited for wet granulation applications.	2.5kg
S494224-PCF-2.5kg	5.5 – 7.5	✓	A	Special grade with max. 0.7 % NaCl recommended for APIs which require a very low ion content.	2.5kg
S494224-Low pH-2.5kg	5.5 – 7.5	✓	B	Special grade with low pH value. Complies with Type B of Ph. Eur, NF, JP.	2.5kg

Names and Identifiers

PubChem CID	47207535

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Shuo Li, Li Shi, Ting Ye, Biao Huang, Yuan Qin, Yongkang Xie, Xiaoyuan Ren, Xueqin Zhao. (2023) Development of Crosslinker-Free Polysaccharide-Lysozyme Microspheres for Treatment Enteric Infection. Polymers, 15 (5): (1077). [PMID:36904318] [10.3390/polym15051077]
2. Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang. (2023) Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, [PMID:36803327] [10.1080/03639045.2023.2182120]
3. Yiyan Gao, Zhixin Zhang, Xiuyan Ren, Fei Jia, Guanghui Gao. (2022) A hydrogel sensor driven by sodium carboxymethyl starch with synergistic enhancement of toughness and conductivity. Journal of Materials Chemistry B, 10 (30): (5743-5752). [PMID:35802130] [10.1039/D2TB00839D]
4. Luhui Wang, Zihao Wei, Changhu Xue. (2022) The presence of propylene glycol alginate increased the stability and intestine-targeted delivery potential of carboxymethyl starch-stabilized emulsions. FOOD RESEARCH INTERNATIONAL, 157 (111387). [PMID:35761643] [10.1016/j.foodres.2022.111387]
5. Amir E. Kaziem, Liupeng Yang, Yigang Lin, Yuting Tan, Zixia Song, Hanhong Xu, Zhixiang Zhang. (2022) Pest Invasion-Responsive Hollow Mesoporous Silica-Linked Carboxymethyl Starch Nanoparticles for Smart Abamectin Delivery. ACS Applied Nano Materials, 5 (3): (3458–3469). [PMID:] [10.1021/acsanm.1c04086]
6. Haq Fazal, Yu Haojie, Wang Li, Teng Lison, Mehmood Sahid, Haroon Muhammad, Bilal-Ul-Amin, Uddin Md Alim, Fahad Shah, Shen Di. (2021) Synthesis of succinylated carboxymethyl starches and their role as adsorbents for the removal of phenol. COLLOID AND POLYMER SCIENCE, 299 (11): (1833-1841). [PMID:] [10.1007/s00396-021-04901-x]
7. Baolei Dong, Hongfang Li, Jiefang Sun, Yuan Li, Ghulam Mujtaba Mari, Xuezhi Yu, Wenbo Yu, Kai Wen, Jianzhong Shen, Zhanhui Wang. (2021) Magnetic assisted fluorescence immunoassay for sensitive chloramphenicol detection using carbon dots@CaCO3 nanocomposites. JOURNAL OF HAZARDOUS MATERIALS, 402 (123942). [PMID:33254829] [10.1016/j.jhazmat.2020.123942]
8. Yuxiang Xue, Qianqian Chang, Xinyu Hu, Jun Cai, Hu Yang. (2020) A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 274 (111184). [PMID:32791324] [10.1016/j.jenvman.2020.111184]
9. Xinliang Li, Guancheng Jiang, Xiulun Shen, Gongrang Li. (2020) Application of Tea Polyphenols as a Biodegradable Fluid Loss Additive and Study of the Filtration Mechanism. ACS Omega, 5 (7): (3453–3461). [PMID:32118159] [10.1021/acsomega.9b03712]
10. Xingtao Chen, Shuyang Li, Yonggang Yan, Jiacan Su, Dongliang Wang, Jun Zhao, Sicheng Wang, Xin Zhang. (2020) Absorbable nanocomposites composed of mesoporous bioglass nanoparticles and polyelectrolyte complexes for surgical hemorrhage control. Materials Science & Engineering C-Materials for Biological Applications, 109 (110556). [PMID:32228979] [10.1016/j.msec.2019.110556]
11. Liang Liu, Ying Zhang, Shuangjiang Yu, Zhen Zhang, Chaoliang He, Xuesi Chen. (2018) pH- and Amylase-Responsive Carboxymethyl Starch/Poly(2-isobutyl-acrylic acid) Hybrid Microgels as Effective Enteric Carriers for Oral Insulin Delivery. BIOMACROMOLECULES, 19 (6): (2123–2136). [PMID:29664632] [10.1021/acs.biomac.8b00215]
12. Huimei Cai, Guijie Chen, Chuanyi Peng, Lingyun Xu, Zhengzhu Zhang, Fei Ke, Xiaochun Wan. (2015) Enhanced fluoride removal by loading Al/Zr onto carboxymethyl starch sodium: synergistic interactions between Al and Zr. RSC Advances, 5 (123): (101819-101825). [PMID:] [10.1039/C5RA18167D]
13. Guisheng Gong, Faai Zhang, Zehong Cheng, Li Zhou. (2015) Facile fabrication of magnetic carboxymethyl starch/poly(vinyl alcohol) composite gel for methylene blue removal. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 81 (205). [PMID:26234575] [10.1016/j.ijbiomac.2015.07.061]
14. Beina Wu, Yaping Guo, Hongmei Cao, Yang Zhang, Lili Yu, Nengqin Jia. (2013) A novel mesoporous molecular sieves-based electrochemilumenescence sensor for sensitive detection of azithromycin. SENSORS AND ACTUATORS B-CHEMICAL, 186 (219). [PMID:] [10.1016/j.snb.2013.05.080]

References

1. Shuo Li, Li Shi, Ting Ye, Biao Huang, Yuan Qin, Yongkang Xie, Xiaoyuan Ren, Xueqin Zhao. (2023) Development of Crosslinker-Free Polysaccharide-Lysozyme Microspheres for Treatment Enteric Infection. Polymers, 15 (5): (1077). [PMID:36904318] [10.3390/polym15051077]
2. Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang. (2023) Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, [PMID:36803327] [10.1080/03639045.2023.2182120]
3. Yiyan Gao, Zhixin Zhang, Xiuyan Ren, Fei Jia, Guanghui Gao. (2022) A hydrogel sensor driven by sodium carboxymethyl starch with synergistic enhancement of toughness and conductivity. Journal of Materials Chemistry B, 10 (30): (5743-5752). [PMID:35802130] [10.1039/D2TB00839D]
4. Luhui Wang, Zihao Wei, Changhu Xue. (2022) The presence of propylene glycol alginate increased the stability and intestine-targeted delivery potential of carboxymethyl starch-stabilized emulsions. FOOD RESEARCH INTERNATIONAL, 157 (111387). [PMID:35761643] [10.1016/j.foodres.2022.111387]
5. Amir E. Kaziem, Liupeng Yang, Yigang Lin, Yuting Tan, Zixia Song, Hanhong Xu, Zhixiang Zhang. (2022) Pest Invasion-Responsive Hollow Mesoporous Silica-Linked Carboxymethyl Starch Nanoparticles for Smart Abamectin Delivery. ACS Applied Nano Materials, 5 (3): (3458–3469). [PMID:] [10.1021/acsanm.1c04086]
6. Haq Fazal, Yu Haojie, Wang Li, Teng Lison, Mehmood Sahid, Haroon Muhammad, Bilal-Ul-Amin, Uddin Md Alim, Fahad Shah, Shen Di. (2021) Synthesis of succinylated carboxymethyl starches and their role as adsorbents for the removal of phenol. COLLOID AND POLYMER SCIENCE, 299 (11): (1833-1841). [PMID:] [10.1007/s00396-021-04901-x]
7. Baolei Dong, Hongfang Li, Jiefang Sun, Yuan Li, Ghulam Mujtaba Mari, Xuezhi Yu, Wenbo Yu, Kai Wen, Jianzhong Shen, Zhanhui Wang. (2021) Magnetic assisted fluorescence immunoassay for sensitive chloramphenicol detection using carbon dots@CaCO3 nanocomposites. JOURNAL OF HAZARDOUS MATERIALS, 402 (123942). [PMID:33254829] [10.1016/j.jhazmat.2020.123942]
8. Yuxiang Xue, Qianqian Chang, Xinyu Hu, Jun Cai, Hu Yang. (2020) A simple strategy for selective photocatalysis degradation of organic dyes through selective adsorption enrichment by using a complex film of CdS and carboxylmethyl starch. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 274 (111184). [PMID:32791324] [10.1016/j.jenvman.2020.111184]
9. Xinliang Li, Guancheng Jiang, Xiulun Shen, Gongrang Li. (2020) Application of Tea Polyphenols as a Biodegradable Fluid Loss Additive and Study of the Filtration Mechanism. ACS Omega, 5 (7): (3453–3461). [PMID:32118159] [10.1021/acsomega.9b03712]
10. Xingtao Chen, Shuyang Li, Yonggang Yan, Jiacan Su, Dongliang Wang, Jun Zhao, Sicheng Wang, Xin Zhang. (2020) Absorbable nanocomposites composed of mesoporous bioglass nanoparticles and polyelectrolyte complexes for surgical hemorrhage control. Materials Science & Engineering C-Materials for Biological Applications, 109 (110556). [PMID:32228979] [10.1016/j.msec.2019.110556]
11. Liang Liu, Ying Zhang, Shuangjiang Yu, Zhen Zhang, Chaoliang He, Xuesi Chen. (2018) pH- and Amylase-Responsive Carboxymethyl Starch/Poly(2-isobutyl-acrylic acid) Hybrid Microgels as Effective Enteric Carriers for Oral Insulin Delivery. BIOMACROMOLECULES, 19 (6): (2123–2136). [PMID:29664632] [10.1021/acs.biomac.8b00215]
12. Huimei Cai, Guijie Chen, Chuanyi Peng, Lingyun Xu, Zhengzhu Zhang, Fei Ke, Xiaochun Wan. (2015) Enhanced fluoride removal by loading Al/Zr onto carboxymethyl starch sodium: synergistic interactions between Al and Zr. RSC Advances, 5 (123): (101819-101825). [PMID:] [10.1039/C5RA18167D]
13. Guisheng Gong, Faai Zhang, Zehong Cheng, Li Zhou. (2015) Facile fabrication of magnetic carboxymethyl starch/poly(vinyl alcohol) composite gel for methylene blue removal. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 81 (205). [PMID:26234575] [10.1016/j.ijbiomac.2015.07.061]
14. Beina Wu, Yaping Guo, Hongmei Cao, Yang Zhang, Lili Yu, Nengqin Jia. (2013) A novel mesoporous molecular sieves-based electrochemilumenescence sensor for sensitive detection of azithromycin. SENSORS AND ACTUATORS B-CHEMICAL, 186 (219). [PMID:] [10.1016/j.snb.2013.05.080]

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Sodium Starch Glycolate - EtOH-based；Ph.Eur., NF, JP, high purity , CAS No.9063-38-1