Selective, high affinity antagonist for the rat and human dopamine D4receptor (Ki= 10 nM). Exhibits low affinity at other monoamine receptors (Ki> 2000 nM). Inducesc-fosgene expression in medial prefrontal cortex in a similar manner toclozapine. Brain pen
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of D 4 receptor
Product Description
Product Describtion:
Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients. In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.
G2303078