Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K i of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC 50 of 40 μM .
In Vitro
Treatment of hepatocytes with Sp-cAMPS sodium salt, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with Glukagon. The Glukagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS sodium salt . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) sodium salt into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
