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SR 2640 hydrochloride , CAS No.105350-26-3, Antagonist of CysLT 1 receptor
an antagonist of leukotriene D4 and E4 receptors
Basic Description Synonyms 105350-26-3|SR 2640|SR-2640|Benzoic acid, 2-[[3-(2-quinolinylmethoxy)phenyl]amino]-|SR2640|2-[3-(quinolin-2-ylmethoxy)anilino]benzoic acid|CHEMBL18132|2-[[3-(2-Quinolinylmethoxy)phenyl]a|SR2640 hydrochloride|2-((3-(Quinolin-2-ylmethoxy)phenyl)amino)benzoi Specifications & Purity Moligand™ Storage Temp Room temperature,Desiccated Shipped In Normal Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of CysLT 1 receptor Product Description SR 2640 Hydrochloride is a potent and selective competitive CysLT1 Receptor (leukotriene D4) and leukotriene E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). SR 2640 Hydrochloride also inhibits LTD4-attenuation of human PMN chemotaxis.
Product Properties Ki Data CysLT1 Receptor: Ki= 2 nM (human)
Names and Identifiers IUPAC Name 2-[3-(quinolin-2-ylmethoxy)anilino]benzoic acid INCHI InChI=1S/C23H18N2O3/c26-23(27)20-9-2-4-11-22(20)24-17-7-5-8-19(14-17)28-15-18-13-12-16-6-1-3-10-21(16)25-18/h1-14,24H,15H2,(H,26,27) InChi Key LMPZHLXYBWGGNT-UHFFFAOYSA-N Canonical SMILES C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=CC(=C3)NC4=CC=CC=C4C(=O)O Isomeric SMILES C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=CC(=C3)NC4=CC=CC=C4C(=O)O PubChem CID 128355 Molecular Weight 406.87
Chemical and Physical Properties Solubility Soluble in DMSO (50 mM). Refractive Index n20D1.71 (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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