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SR8185 , CAS No.S613700, Inhibitor of inhibitor of nuclear factor kappa B kinase subunit epsilon;Inhibitor of TANK binding kinase 1

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SR8185 , CAS No.S613700, Inhibitor of inhibitor of nuclear factor kappa B kinase subunit epsilon;Inhibitor of TANK binding kinase 1

Moligand™

PubChem CID: 56646418

Item Number

S613700

Grouped product items
SKU	Size	Availability	Price	Qty
S613700-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
S613700-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

inhibitor of nuclear factor kappa B kinase subunit epsilon Inhibitor TANK binding kinase 1 Inhibitor

Basic Description

Synonyms	SR-8185
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of inhibitor of nuclear factor kappa B kinase subunit epsilon;Inhibitor of TANK binding kinase 1

Associated Targets

IKBKE Tchem Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1 Activities

Discover Target: IKBKE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBK1 Tchem Serine/threonine-protein kinase TBK1 1 Activities

Discover Target: TBK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[3-[[4-(3-cyano-4-pyrrolidin-1-ylphenyl)pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide
INCHI	InChI=1S/C26H27N7O/c27-18-20-16-19(8-9-24(20)32-12-1-2-13-32)23-10-11-28-25(31-23)29-21-6-5-7-22(17-21)30-26(34)33-14-3-4-15-33/h5-11,16-17H,1-4,12-15H2,(H,30,34)(H,28,29,31)
InChi Key	MQAQKNLCUSPSAF-UHFFFAOYSA-N
Canonical SMILES	N#Cc1cc(ccc1N1CCCC1)c1ccnc(n1)Nc1cccc(c1)NC(=O)N1CCCC1
Isomeric SMILES	C1CCN(C1)C2=C(C=C(C=C2)C3=NC(=NC=C3)NC4=CC(=CC=C4)NC(=O)N5CCCC5)C#N
PubChem CID	56646418

Database links

PubChem CID	56646418

Certificates

Certificate of Analysis(COA)

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References

1. Li J, Huang J, Jeong JH, Park SJ, Wei R, Peng J, Luo Z, Chen YT, Feng Y, Luo JL. (2014) Selective TBK1/IKKi dual inhibitors with anticancer potency.. Int J Cancer, 134 (8): (1972-80). [PMID:24150799]

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