Src Inhibitor 3 is a potent, orally active c-terminal Src kinase (CSK) with IC 50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. Src Inhibitor 3 shows the ability to increase T cell proliferation induced by T cell receptor signaling
In Vivo
Src Inhibitor 3 reduces inhibitory LCK phosphorylation in vivo upon oral dosing and shows the ability to enhance T cell activation in response to antigen stimulation . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: <3 nM (c-terminal Src kinase in CSK HTRF assay), 4 nM (c-terminal Src kinase in Caliper assay)
