Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM.
In Vitro
Stearoyl-L-carnitine (0.01-10 μM) inhibits glycine (30 μM) transports by 16.8% at concentrations up 3 μM in Xenopus laevis oocytes. Stearoyl-L-carnitine (500 μM; 30 min) inhibits Na + -dependent [ 3 H]carnitine (20 nM) uptake by ~50% in HPCT cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Stearoyl-L-carnitine is significantly decreased in Alzheimer's disease (AD), mild cognitive impairment (MCI) and subjective memory complaint (SMC) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
