STX-100 (anti-Integrin aVb6 (ITGAV & ITGB6)) is a humanized monoclonal antibody directed against the alpha v beta 6 (αvβ6) integrin. It has a potential to be used in research on Idiopathic Pulmonary Fibrosis (IPF). Purity ≥95% (SDS-PAGE&SEC) Endotoxin Level ≤1.0EU/mg Protein Function ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. ITGB6: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Product Properties
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
145.12 kDa
Purification Method
Protein A purified
Concentration
Lot by Lot
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
1439902-67-6
Images
STX-100 (anti-Integrin aVb6) (Ab182704) - Flow Cytometry Flow Cytometry analysis of MCF-7 cells labelling Integrin aVb6 (red) with STX-100 (anti-Integrin aVb6) (Ab182704) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
STX-100 (anti-Integrin aVb6) (Ab182704) - ELISA Immobilized Human Integrin alpha V beta 6 (ITGAV&ITGB6) at 2.0 μg/mL can bind STX-100 (anti-Integrin aVb6) (Ab182704) with the EC₅₀ of 131.5 ng/mL.
