SU4312 - ≥98%, high purity , CAS No.5812-07-7, Inhibitor of kinase insert domain receptor

Item Number

S275815

• Synonyms: (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one | HMS3403B19 | BMK1-F6 | NCGC00025170-14 | NSC 86429 | BCP20743 | HMS1792B19 | SU4312(NSC86429) | 3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one | NCGC00025170-03 | NCGC00025170-07
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Potent, selective VEGFR and PDGFR tyrosine kinases inhibitor (IC 50 values are 0.8 and 19.4 μM respectively). Shows anti-angiogenic effects. Active in vivo .
• Storage Temp: Protected from light,Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of kinase insert domain receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0μM, respectively.