| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S649223-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $94.90 |
| Synonyms | {4-[4-[Bis-(4-fluorophenyl)methyl]piperizin-1-yl]-(E)-but-2-enyloxy}acetic Acid Dihydrochloride | AKOS040739467 | SUN 1334H | SCHEMBL5623924 | CS-6696 | KAQMKGKFTBFMGE-SEPHDYHBSA-N | SCHEMBL1138186 | 2-[(E)-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]b |
|---|---|
| Biochemical and Physiological Mechanisms | SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with K i of 9.7 nM. |
| Storage Temp | Store at 2-8°C,Desiccated |
| Shipped In | Wet ice |
| Product Description | SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with K i of 9.7 nM. In Vitro SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC 50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K + -currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs . In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 9.7 nM (H1 receptor) |
| IUPAC Name | 2-[(E)-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]but-2-enoxy]acetic acid;dihydrochloride |
|---|---|
| INCHI | InChI=1S/C23H26F2N2O3.2ClH/c24-20-7-3-18(4-8-20)23(19-5-9-21(25)10-6-19)27-14-12-26(13-15-27)11-1-2-16-30-17-22(28)29;;/h1-10,23H,11-17H2,(H,28,29);2*1H/b2-1+;; |
| InChi Key | KAQMKGKFTBFMGE-SEPHDYHBSA-N |
| Canonical SMILES | C1CN(CCN1CC=CCOCC(=O)O)C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F.Cl.Cl |
| Isomeric SMILES | C1CN(CCN1C/C=C/COCC(=O)O)C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F.Cl.Cl |
| Alternate CAS | 607736-84-5 |
| PubChem CID | 69509032 |
| MeSH Entry Terms | 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid;SUN 1334H;SUN-1334H;SUN1334H |
| Molecular Weight | 489.38 |
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