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SVEP1, CAS No.rp175251, integrin; alpha 9 subunit

  • Moligand™
Features and benefits
    Item Number
    rp175251
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp175251-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp175251-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
    View related series
    integrin,alpha 9 subunit

    Basic Description

    Product NameSVEP1, CAS No.rp175251
    Synonymspolydom
    GradeMoligand™
    Mechanism of actionintegrin; alpha 9 subunit

    Associated Targets

    ITGA9 Tbio Integrin alpha-9 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp175251

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Alternate Namespolydom
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Sato-Nishiuchi R, Nakano I, Ozawa A, Sato Y, Takeichi M, Kiyozumi D, Yamazaki K, Yasunaga T, Futaki S, Sekiguchi K.  (2012)  Polydom/SVEP1 is a ligand for integrin α9β1..  J Biol Chem,  287  (30): (25615-30).  [PMID:22654117]
    2. Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL et al..  (2016)  Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease..  N Engl J Med,  374  (12): (1134-44).  [PMID:26934567]
    3. Jung IH, Elenbaas JS, Alisio A, Santana K, Young EP, Kang CJ, Kachroo P, Lavine KJ, Razani B, Mecham RP et al..  (2021)  SVEP1 is a human coronary artery disease locus that promotes atherosclerosis..  Sci Transl Med,  13  (586): (589-97).  [PMID:33762433]
    4. Michelini S, Amato B, Ricci M, Serrani R, Veselenyiova D, Kenanoglu S, Kurti D, Dautaj A, Baglivo M, Compagna R et al..  (2021)  SVEP1 is important for morphogenesis of lymphatic system: Possible implications in lymphedema..  Lymphology,  54  (1): (12-22).  [PMID:34506084]
    5. Morris GE, Denniff MJ, Karamanavi E, Andrews SA, Kostogrys RB, Bountziouka V, Ghaderi-Najafabadi M, Shamkhi N, McConnell G, Kaiser MA et al..  (2022)  The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1..  Br J Pharmacol,  179  (21): (4958-4973).  [PMID:35802072]
    6. Chen L, Liu D, Yi X, Qi L, Tian X, Sun B, Dong Q, Han Z, Li Q, Song T et al..  (2020)  The novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway..  Cell Death Dis,  11  (5): (320).  [PMID:32371982]

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