T0070907 - ≥99%, high purity , CAS No.313516-66-4, Antagonist of Peroxisome proliferator-activated receptor-γ

Item Number

T125937

• Synonyms: 313516-66-4 | T0070907 | 2-CHLORO-5-NITRO-N-4-PYRIDINYLBENZAMIDE | 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide | 2-chloro-5-nitro-N-pyridin-4-ylbenzamide | T 0070907 | T-0070907 | Benzamide, 2-chloro-5-nitro-N-4-pyridinyl- | 2-Chloro-5-nitro-N-(4-pyridyl)benzamide | MFCD001
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: T0070907 is a potent and selective PPARγ antagonist (IC50 = 1 nM). T0070907 displays > 800-fold selectivity for PPARγ over PPARα and PPARδ. Blocks transcriptional activity of PPARγ in vitro and inhibits rosiglitazone-induced adi
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of Peroxisome proliferator-activated receptor-γ
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line.It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.

T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection.

T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.