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SKU

Size

Availability

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T109477-5g

Available within 4-8 weeks(?)

$36.90

T109477-25g

25g

Available within 4-8 weeks(?)

$127.90

T109477-100g

100g

Available within 4-8 weeks(?)

$409.90

T109477-500g

500g

Available within 8-12 weeks(?)

$999.90

Basic Description

Synonyms	2,2-Trichloroethoxycarbonyl chloride \| .BETA.,.BETA.,.BETA.-TRICHLOROETHOXYCARBONYL CHLORIDE \| AKOS015917631 \| Trichloroethyl chloroformate \| 2,2,2-trichloroethylchloroformate \| 2,2,2-trichloroethyl-chloroformate \| Carbonochloridic acid,2,2-trichloroethyl
Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Product Description	2,2,2-Trichloroethyl chloroformate (TrocCl) serves as a versatile reagent used for selective acylation and dealkylation in organic synthesis. It is used in regio, chemo, and stereoselective synthesis. 2,2,2-Trichloroethyl chloroformate was used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples； It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester； It was used as reagent during N-demethylation of dextromethorphan； It was used as protecting reagent for aliphatic and aromatic hydroxyl and amino groups； Protecting reagent for aliphatic and aromatic hydroxyl and amino groups.

Names and Identifiers

IUPAC Name	2,2,2-trichloroethyl carbonochloridate
INCHI	InChI=1S/C3H2Cl4O2/c4-2(8)9-1-3(5,6)7/h1H2
InChi Key	LJCZNYWLQZZIOS-UHFFFAOYSA-N
Canonical SMILES	C(C(Cl)(Cl)Cl)OC(=O)Cl
Isomeric SMILES	C(C(Cl)(Cl)Cl)OC(=O)Cl
WGK Germany	3
PubChem CID	87063
UN Number	3277
Molecular Weight	211.86
Beilstein	970619

Certificates

Certificate of Analysis(COA)

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15 results found

Lot Number	Certificate Type	Date	Item
H2430524	Certificate of Analysis	Aug 16, 2024	T109477
H2430527	Certificate of Analysis	Aug 16, 2024	T109477
G2415814	Certificate of Analysis	Jul 02, 2024	T109477
C2426354	Certificate of Analysis	Mar 11, 2024	T109477
C2426355	Certificate of Analysis	Mar 11, 2024	T109477
C2426356	Certificate of Analysis	Mar 11, 2024	T109477
I2320312	Certificate of Analysis	Aug 21, 2023	T109477
I2320329	Certificate of Analysis	Aug 21, 2023	T109477
F2306784	Certificate of Analysis	Feb 20, 2023	T109477
G2430140	Certificate of Analysis	Feb 20, 2023	T109477
K2222739	Certificate of Analysis	Sep 02, 2022	T109477
K2222872	Certificate of Analysis	Sep 02, 2022	T109477
K2222873	Certificate of Analysis	Sep 02, 2022	T109477
K2222874	Certificate of Analysis	Sep 02, 2022	T109477
H2204192	Certificate of Analysis	Nov 17, 2021	T109477

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Chemical and Physical Properties

Solubility	Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
Sensitivity	Moisture sensitive.
Refractive Index	1.469-1.471
Boil Point(°C)	171-172°C
Melt Point(°C)	1°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS05, GHS07
Signal	Danger
Hazard Statements	H331:Toxic if inhaled H314:Causes severe skin burns and eye damage H302:Harmful if swallowed H330:Fatal if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately.
WGK Germany	3

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jinxia An, Xiaomei Dai, Yu Zhao, Qianqian Guo, Zhongming Wu, Xinge Zhang, Chaoxing Li. (2015) A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells. Polymer Chemistry, 6 (36): (6529-6542). [PMID:]

References

1. P Hartvig,C Fagerlund. (1983-05-13) A simplified method for the gas chromatographic determination of pethidine and norpethidine after derivatization with trichloroethyl chloroformate.. Journal of chromatography, 274 (355-360). [PMID:6874840]
2. A M Crider,R Grubb,K A Bachmann,A K Rawat. (1981-12-01) Convenient synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester.. Journal of pharmaceutical sciences, 70 ((12)): (1319-1321). [PMID:7198684]
3. N P Peet. (1980-12-01) N-Demethylation of dextromethorphan.. Journal of pharmaceutical sciences, 69 ((12)): (1447-1448). [PMID:7463337]
4. A Dasgupta,P Appenzeller,J Moore. (1998-06-19) Gas chromatography-electron ionization and chemical ionization mass spectrometric analysis of serum mexiletine concentration after derivatization with 2,2,2-trichloroethyl chloroformate: a novel derivative.. Therapeutic drug monitoring, 20 ((3)): (313-318). [PMID:9631929]
5. A Dasgupta. (1998-11-21) Gas chromatographic-mass spectrometric identification and quantification of aniline after extraction from serum and derivatization with 2,2,2-trichloroethyl chloroformate, a novel derivative.. Journal of chromatography. B, Biomedical sciences and applications, 716 ((1-2)): (354-358). [PMID:9824251]
6. Giampietro Frison,Luciano Tedeschi,Donata Favretto,Aikebaier Reheman,Santo Davide Ferrara. (2005-03-05) Gas chromatography/mass spectrometry determination of amphetamine-related drugs and ephedrines in plasma, urine and hair samples after derivatization with 2,2,2-trichloroethyl chloroformate.. Rapid communications in mass spectrometry : RCM, 19 ((7)): (919-927). [PMID:15747332]
7. Giampietro Frison,Maria Gregio,Luca Zamengo,Flavio Zancanaro,Samuela Frasson,Rocco Sciarrone. (2010-12-31) Gas chromatography/mass spectrometry determination of mephedrone in drug seizures after derivatization with 2,2,2-trichloroethyl chloroformate.. Rapid communications in mass spectrometry : RCM, 25 ((2)): (387-390). [PMID:21192034]
8. Fei Li. (2011-05-31) [An accident of chloroethyl chloroformate poisoning].. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 29 ((1)): (38-38). [PMID:21619795]
9. Giampietro Frison,Sara Odoardi,Samuela Frasson,Rocco Sciarrone,Giorgio Ortar,Francesco Saverio Romolo,Sabina Strano Rossi. (2015-09-24) Characterization of the designer drug bk-2C-B (2-amino-1-(bromo-dimethoxyphenyl)ethan-1-one) by gas chromatography/mass spectrometry without and with derivatization with 2,2,2-trichloroethyl chloroformate, liquid chromatography/high-resolution mass spectrometry, and nuclear magnetic resonance.. Rapid communications in mass spectrometry : RCM, 29 ((13)): (1196-1204). [PMID:26395784]
10. J O Kuye,M J Wilson,T Walle. (1983-02-11) Gas chromatographic analysis of chloroquine after a unique reaction with chloroformates.. Journal of chromatography, 272 ((2)): (307-313). [PMID:6833427]
11. A Dasgupta,J Spies. (1998-05-12) A rapid novel derivatization of amphetamine and methamphetamine using 2,2,2-trichloroethyl chloroformate for gas chromatography electron ionization and chemical ionization mass spectrometric analysis.. American journal of clinical pathology, 109 ((5)): (527-532). [PMID:9576569]
12. A Dasgupta,M S Handler,J S Nine. (1998-06-03) A convenient derivatization method for gas chromatography/mass spectrometric determination of phenmetrazine in urine using 2,2,2-trichloroethyl chloroformate.. Journal of forensic sciences, 43 ((3)): (630-635). [PMID:9608701]
13. E M Smyth,S C Austin,M P Reilly,G A FitzGerald. (2000-07-13) Internalization and sequestration of the human prostacyclin receptor.. The Journal of biological chemistry, 275 ((41)): (32037-32045). [PMID:10889200]
14. Jinxia An, Xiaomei Dai, Yu Zhao, Qianqian Guo, Zhongming Wu, Xinge Zhang, Chaoxing Li. (2015) A biodegradable and fluorescent nanovehicle with enhanced selective uptake by tumor cells. Polymer Chemistry, 6 (36): (6529-6542). [PMID:]

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2,2,2-Trichloroethyl chloroformate - 99%, high purity , CAS No.17341-93-4

Basic Description

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

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SKU	Size	Availability	Price
T109477-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$36.90
T109477-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$127.90
T109477-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$409.90
T109477-500g	500g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$999.90