Tacrolimus Monohydrate - ≥80.0%(HPLC), high purity , CAS No.109581-93-3

Item Number

F138016

Grouped product items
SKU	Size	Availability	Price
F138016-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$68.90
F138016-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$88.90
F138016-250mg	250mg	In stock	$400.90
F138016-1g	1g	In stock	$1,441.90

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Basic Description

Synonyms	TACROLIMUS MONOHYDRATE\|Tacrolimus hydrate\|109581-93-3\|Prograf\|Protopic\|Tsukubaenolide hydrate\|FK-506 monohydrate\|LCP-Tacro\|Tacrolimus (monohydrate)\|WM0HAQ4WNM\|FK 506\|Tacrolimus [USAN]\|FR900506\|FR 900506\|UNII-WM0HAQ4WNM\|Prograf (TN)\|(1R,9S,12S,13R,14S,17R,
Specifications & Purity	≥80.0%(HPLC)
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Dry ice
Product Description	Application FK-506 monohydrate has been used: as an immunosuppressive agent in coculture medium to study the effect of immunologic reaction as a calcineurin inhibitor, in anhydrous Me2SO solution to treat retinal pigment epithelial cells to measure possible cytotoxicity

Names and Identifiers

IUPAC Name	(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone;hydrate
INCHI	InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
InChi Key	NWJQLQGQZSIBAF-MLAUYUEBSA-N
Canonical SMILES	CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC.O
Isomeric SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC.O
WGK Germany	3
RTECS	KD4201200
PubChem CID	5282315
Molecular Weight	822.03
Reaxy-Rn	6265275

Certificates

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9 results found

Lot Number	Certificate Type	Date	Item
D1719102	Certificate of Analysis	Jul 08, 2024	F138016
I2203244	Certificate of Analysis	Jun 17, 2024	F138016
I2203245	Certificate of Analysis	Jun 17, 2024	F138016
H2309731	Certificate of Analysis	Aug 14, 2023	F138016
H2301065	Certificate of Analysis	Aug 10, 2023	F138016
H2301056	Certificate of Analysis	Aug 10, 2023	F138016
H2301069	Certificate of Analysis	Aug 10, 2023	F138016
K1928103	Certificate of Analysis	Jul 17, 2023	F138016
A1925046	Certificate of Analysis	Sep 21, 2022	F138016

Solubility

Soluble in 20 mg/mL of DMSO

Sensitivity

light & heat sensitive

Melt Point(°C)

127 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RTECS	KD4201200
Reaxy-Rn	6265275
Merck Index	9025

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Basic Description