TAE226 (NVP-TAE226) - ≥99%, high purity , CAS No.761437-28-9, Inhibitor of Insulin-like growth factor I receptor;Inhibitor of Insulin receptor;Inhibitor of protein tyrosine kinase 2;Inhibitor of protein tyrosine kinase 2 beta
TAE226 (NVP-TAE226) - ≥99%, high purity , CAS No.761437-28-9, Inhibitor of Insulin-like growth factor I receptor;Inhibitor of Insulin receptor;Inhibitor of protein tyrosine kinase 2;Inhibitor of protein tyrosine kinase 2 beta
NVP-TAE 226(TAE226) is a potent dual FAK/IGF-IR kinase inhibitor.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of Insulin-like growth factor I receptor;Inhibitor of Insulin receptor;Inhibitor of protein tyrosine kinase 2;Inhibitor of protein tyrosine kinase 2 beta
Note
卖完停产，不再备货
Product Description
TAE226 (NVP-TAE226) is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2, ~10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met
1.Shi Q, Hjelmeland AB, Keir ST, Song L, Wickman S, Jackson D, Ohmori O, Bigner DD, Friedman HS, Rich JN. (2007) A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.. Mol Carcinog, 46 (6):(488-96). [PMID:17219439]
2.Liu TJ, LaFortune T, Honda T, Ohmori O, Hatakeyama S, Meyer T, Jackson D, de Groot J, Yung WK. (2007) Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.. Mol Cancer Ther, 6 (4):(1357-67). [PMID:17431114]
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C1602040