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TAK-715 - ≥99%, high purity , MAP kinase p38 alpha inhibitor, CAS No.303162-79-0, MAP kinase p38 alpha inhibitor
Potent p38 MAPK inhibitor
Basic Description Synonyms TAK-715|303162-79-0|TAK 715|N-(4-(2-ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide|TAK715|Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-|CHEMBL363648|WE92U03C5Z|N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]b Specifications & Purity ≥99% Storage Temp Store at -20°C Shipped In Dry ice Grade Moligand™ Action Type INHIBITOR Mechanism of action MAP kinase p38 alpha inhibitor Product Description TAK-715
Names and Identifiers Pubchem Sid 488196465 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196465 IUPAC Name N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]benzamide INCHI InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28) InChi Key HEKAIDKUDLCBRU-UHFFFAOYSA-N Canonical SMILES CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C Isomeric SMILES CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC=CC(=C4)C WGK Germany 3 PubChem CID 9952773 Molecular Weight 399.51
Chemical and Physical Properties Solubility DMSO≥40 mg/mL in DMSO; insoluble in H2O; ≥12.13 mg/mL in EtOH with ultrasonic
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
WGK Germany 3
References 1. Miwatashi S, Arikawa Y, Kotani E, Miyamoto M, Naruo K, Kimura H, Tanaka T, Asahi S, Ohkawa S. (2005) Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.. J Med Chem, 48 (19): (5966-79). [PMID:16162000 ]
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