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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T288176-5mg | 5mg | In stock | $78.90 | |
T288176-10mg | 10mg | In stock | $147.90 | |
T288176-25mg | 25mg | In stock | $333.90 | |
T288176-50mg | 50mg | In stock | $444.90 | |
T288176-100mg | 100mg | In stock | $741.90 |
Potent and selective TAK1/MAP3K7 kinase inhibitor
Synonyms | Takinib|1111556-37-6|EDHS-206|3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide|Z56NTB3YHJ|N1-(1-Propyl-1H-benzo[d]imidazol-2-yl)isophthalamide|MFCD11822633|1,3-Benzenedicarboxamide, N1-(1-propyl-1H-benzimidazol-2-yl)-|N1-(1-Propyl-1H-benzimidazol- |
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Specifications & Purity | ≥98%(HPLC) |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of CDC like kinase 2;Inhibitor of interleukin 1 receptor associated kinase 1;Inhibitor of interleukin 1 receptor associated kinase 4;Inhibitor of mitogen-activated protein kinase kinase kinase 7 |
Product Description | Application Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells. |
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IUPAC Name | 3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide |
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INCHI | InChI=1S/C18H18N4O2/c1-2-10-22-15-9-4-3-8-14(15)20-18(22)21-17(24)13-7-5-6-12(11-13)16(19)23/h3-9,11H,2,10H2,1H3,(H2,19,23)(H,20,21,24) |
InChi Key | UOZVVPXKJGOFIG-UHFFFAOYSA-N |
Canonical SMILES | CCCN1C2=CC=CC=C2N=C1NC(=O)C3=CC=CC(=C3)C(=O)N |
Isomeric SMILES | CCCN1C2=CC=CC=C2N=C1NC(=O)C3=CC=CC(=C3)C(=O)N |
Alternate CAS | 1111556-37-6 |
PubChem CID | 37750349 |
MeSH Entry Terms | EDHS-206;takinib |
Molecular Weight | 322.37 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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C2301324 | Certificate of Analysis | Sep 06, 2022 | T288176 |
C2301325 | Certificate of Analysis | Sep 06, 2022 | T288176 |
C2301326 | Certificate of Analysis | Sep 06, 2022 | T288176 |
C2301328 | Certificate of Analysis | Sep 06, 2022 | T288176 |
C2301329 | Certificate of Analysis | Sep 06, 2022 | T288176 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 32.24, Max Conc. mM: 100 |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
RIDADR | NONHforallmodesoftransport |
1. Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM et al.. (2017) Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.. Cell Chem Biol, 24 (8): (1029-1039.e7). [PMID:28820959] |
2. Scarneo SA, Mansourati A, Eibschutz LS, Totzke J, Roques JR, Loiselle D, Carlson D, Hughes P, Haystead TAJ. (2018) Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion.. Sci Rep, 8 (1): (17058). [PMID:30451876] |