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Takinib , CAS No.T614320, Inhibitor of CDC like kinase 2;Inhibitor of interleukin 1 receptor associated kinase 1;Inhibitor of interleukin 1 receptor associated kinase 4;Inhibitor of mitogen-activated protein kinase kinase kinase 7

Moligand™

PubChem CID: 37750349

Item Number

T614320

Grouped product items
SKU	Size	Availability	Price	Qty
T614320-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
T614320-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

CDC like kinase 2 Inhibitor interleukin 1 receptor associated kinase 1 Inhibitor interleukin 1 receptor associated kinase 4 Inhibitor mitogen-activated protein kinase kinase kinase 7 Inhibitor

Basic Description

Synonyms	Takinib\|1111556-37-6\|EDHS-206\|3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide\|Z56NTB3YHJ\|N1-(1-Propyl-1H-benzo[d]imidazol-2-yl)isophthalamide\|MFCD11822633\|1,3-Benzenedicarboxamide, N1-(1-propyl-1H-benzimidazol-2-yl)-\|N1-(1-Propyl-1H-benzimidazol-
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of CDC like kinase 2;Inhibitor of interleukin 1 receptor associated kinase 1;Inhibitor of interleukin 1 receptor associated kinase 4;Inhibitor of mitogen-activated protein kinase kinase kinase 7

Associated Targets

IRAK4 Tchem Interleukin-1 receptor-associated kinase 4 1 Activities

Discover Target: IRAK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IRAK1 Tchem Interleukin-1 receptor-associated kinase 1 1 Activities

Discover Target: IRAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K7 Tchem Mitogen-activated protein kinase kinase kinase 7 1 Activities

Discover Target: MAP3K7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK2 Tchem Dual specificity protein kinase CLK2 1 Activities

Discover Target: CLK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide
INCHI	InChI=1S/C18H18N4O2/c1-2-10-22-15-9-4-3-8-14(15)20-18(22)21-17(24)13-7-5-6-12(11-13)16(19)23/h3-9,11H,2,10H2,1H3,(H2,19,23)(H,20,21,24)
InChi Key	UOZVVPXKJGOFIG-UHFFFAOYSA-N
Canonical SMILES	CCCn1/c(=N/C(=O)c2cccc(c2)C(=O)N)/[nH]c2c1cccc2
Isomeric SMILES	CCCN1C2=CC=CC=C2N=C1NC(=O)C3=CC=CC(=C3)C(=O)N
PubChem CID	37750349

PubChem CID

37750349

RCSB PDB Ligand

EDH

References

1. Totzke J, Gurbani D, Raphemot R, Hughes PF, Bodoor K, Carlson DA, Loiselle DR, Bera AK, Eibschutz LS, Perkins MM et al.. (2017) Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.. Cell Chem Biol, 24 (8): (1029-1039.e7). [PMID:28820959]
2. Scarneo SA, Mansourati A, Eibschutz LS, Totzke J, Roques JR, Loiselle D, Carlson D, Hughes P, Haystead TAJ. (2018) Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion.. Sci Rep, 8 (1): (17058). [PMID:30451876]

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