Tanezumab (anti-NGF) - Primary antibody, specific to NGF, Human IgG2, INHIBITOR of Beta-nerve growth factor inhibitor

Features and benefits

Short Overview:
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Human IgG2

Application:

Item Number

Ab175666

Grouped product items
SKU	Size	Availability	Price
Ab175666-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$39.90
Ab175666-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$179.90
Ab175666-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$449.90
Ab175666-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$719.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

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Basic Description

Product Name	Tanezumab (anti-NGF) - Primary antibody, specific to NGF, Human IgG2
Synonyms	PF-04383119;PF04383119;RN624
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Specificity	NGF
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	INHIBITOR
Mechanism of action	INHIBITOR of Beta-nerve growth factor inhibitor
Product Description	Tanezumab (anti-NGF) is a humanized anti-NGF mAb with high affinity and specificity. Tanezumab (anti-NGF) blocks NGF binding to its receptors, p75 and TrkA, in the peripheral nervous system. Tanezumab (anti-NGF) can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg

Product Properties

Isotype	Human IgG2
Light Chain Type	kappa
SDS-PAGE	26.7 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 194.4 kDa, under non-reducing conditions.
Purification Method	Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	880266-57-9

IMGT/mAb-DB

Wikipedia

Certificates

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3 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0404822	Certificate of Analysis	Apr 24, 2024	Ab175666
ZJ24F0404821	Certificate of Analysis	Apr 24, 2024	Ab175666
ZJ24F0404820	Certificate of Analysis	Apr 24, 2024	Ab175666

References

1. Brown MT, Murphy FT, Radin DM, Davignon I, Smith MD, West CR. (2013) Tanezumab reduces osteoarthritic hip pain: results of a randomized, double-blind, placebo-controlled phase III trial.. Arthritis Rheum, 65 (7): (1795-803). [PMID:23553790]
2. Gimbel JS, Kivitz AJ, Bramson C, Nemeth MA, Keller DS, Brown MT, West CR, Verburg KM. (2014) Long-term safety and effectiveness of tanezumab as treatment for chronic low back pain.. Pain, 155 (9): (1793-801). [PMID:24937440]
3. Hochberg MC. (2015) Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies.. Osteoarthr Cartil, 23 Suppl 1 (3): (S18-21). [PMID:25527216]
4. Bramson C, Herrmann DN, Carey W, Keller D, Brown MT, West CR, Verburg KM, Dyck PJ. (2015) Exploring the role of tanezumab as a novel treatment for the relief of neuropathic pain.. Pain Med, 16 (6): (1163-76). [PMID:25594611]
5. Sopata M, Katz N, Carey W, Smith MD, Keller D, Verburg KM, West CR, Wolfram G, Brown MT. (2015) Efficacy and safety of tanezumab in the treatment of pain from bone metastases.. Pain, 156 (9): (1703-13). [PMID:25919474]

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Basic Description