Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

RASEF

DescriptionRas and EF-hand domain-containing protein

Gene and Protein Information

Gene ID158158
Uniprot Accession IDs Q8IZ41 A6NC29 Q96N04
Ensembl ID ENSP00000365630
Symbol RAB45 RAB45
FamilyBelongs to the small GTPase superfamily. Rab family.
Sequence
MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCCNG
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp464548RASEFRAS and EF-hand domain containing9598VGNC:13951OMA, EggNOG
Mouse242505RasefRAS and EF hand domain containing10090MGI:2448565Inparanoid, OMA, EggNOG
Rat298138RasefRAS and EF hand domain containing10116RGD:1306418OMA, EggNOG
Dog484152RASEFRAS and EF-hand domain containing9615VGNC:45366Inparanoid, OMA, EggNOG
Horse100055690RASEFRAS and EF-hand domain containing9796VGNC:22195Inparanoid, OMA, EggNOG
Cow513223RASEFRAS and EF-hand domain containing9913VGNC:33742Inparanoid, OMA, EggNOG
Opossum100021794RASEFRAS and EF-hand domain containing13616Inparanoid, OMA, EggNOG
PlatypusRASEFRAS and EF-hand domain containing [Source:HGNC Symbol;Acc:HGNC:26464]9258OMA, EggNOG
Chicken427451RASEFRAS and EF-hand domain containing9031CGNC:53092OMA, EggNOG
Anole lizard100559442rasefRAS and EF-hand domain containing28377Inparanoid, OMA, EggNOG
Xenopus780339rasefRAS and EF-hand domain containing8364Inparanoid, OMA, EggNOG
Zebrafish570731rasefRAS and EF-hand domain containing7955ZDB-GENE-081105-157OMA, EggNOG
C. elegans180593rsef-1Ras and EF-hand domain-containing protein homolog6239Inparanoid, OMA, EggNOG

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      adult high grade glioma4998Expression AtlasMONDO:0100342
      breast carcinoma2011Expression AtlasMONDO:0004989
      cystic fibrosis1831Expression AtlasMONDO:0009061
      ductal carcinoma in situ1737Expression AtlasMONDO:0005023
      ependymoma5607Expression AtlasMONDO:0021191
      fibroadenoma560Expression AtlasMONDO:0002056
      glioblastoma5998Expression AtlasMONDO:0018177
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959
      interstitial cystitis2307Expression AtlasMONDO:0018301
      intraductal papillary-mucinous adenoma (IPMA)2987Expression AtlasMONDO:0004381

      Bibliography

      1.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      2.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      3.Shintani, Mami M and 5 more authors. 2007-06-08 Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. [PMID:17448446]
      4.Maat, Willem W and 5 more authors. 2008-04 Epigenetic regulation identifies RASEF as a tumor-suppressor gene in uveal melanoma. [PMID:18385040]
      5.Nakamura, Satoki S and 10 more authors. 2011-12 Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells. [PMID:21890458]
      6.Tian, Lijun L, McClafferty, Heather H, Knaus, Hans-Guenther HG, Ruth, Peter P and Shipston, Michael J MJ. 2012-04-27 Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. [PMID:22399288]
      7.Comuzzie, Anthony G AG and 6 more authors. 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. [PMID:23251661]
      8.Kaplon, Joanna J and 7 more authors. 2014-07 Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma. [PMID:24703243]
      9.Wang, Yuxiao Y and 5 more authors. 2019-05-06 CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic. [PMID:30814157]
      10.Bonaldo, M F MF, Lennon, G G and Soares, M B MB. 1996-09 Normalization and subtraction: two approaches to facilitate gene discovery. [PMID:8889548]