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PDE2A

DescriptioncGMP-dependent 3',5'-cyclic phosphodiesterase

Gene and Protein Information

Gene ID5138
Uniprot Accession IDs B2R646 B3KRV5 E9PGI1 F6W5Z0 Q5J791 Q5J792 Q5J793 Q6ZMR1
Ensembl ID ENSP00000334910
Symbol PDE2A1 PED2A4 cGSPDE CGS-PDE
FamilyBelongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
Sequence
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp451405PDE2Aphosphodiesterase 2A9598VGNC:3074OMA, EggNOG
Macaque718479PDE2Aphosphodiesterase 2A9544OMA, EggNOG
Rat81743Pde2aphosphodiesterase 2A10116RGD:620965OMA, EggNOG
Dog609574PDE2Aphosphodiesterase 2A9615VGNC:44351OMA, EggNOG
Horse100052619PDE2Aphosphodiesterase 2A9796VGNC:21242OMA, EggNOG
Cow281971PDE2Aphosphodiesterase 2A9913VGNC:32674OMA, EggNOG
Pig100737701PDE2Aphosphodiesterase 2A9823OMA, EggNOG
Opossum100014975PDE2Aphosphodiesterase 2A13616OMA, EggNOG
Xenopuspde2aphosphodiesterase 2A [Source:Xenbase;Acc:XB-GENE-5945995]8364OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant PDE2A AntibodyHuman,Mouse,Rat
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      adult high grade glioma4998Expression AtlasMONDO:0100342
      astrocytic glioma3773Expression AtlasMONDO:0021636
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      breast carcinoma2011Expression AtlasMONDO:0004989
      ductal carcinoma in situ1737Expression AtlasMONDO:0005023
      ependymoma5607Expression AtlasMONDO:0021191
      fibroadenoma560Expression AtlasMONDO:0002056
      glioblastoma5998Expression AtlasMONDO:0018177
      intraductal papillary-mucinous neoplasm (IPMN)3325Expression AtlasMONDO:0004286

      Bibliography

      1.Sadhu, K K, Hensley, K K, Florio, V A VA and Wolda, S L SL. 1999-07 Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells. [PMID:10375378]
      2.Zauli, G G and 6 more authors. 2001-02 HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. [PMID:11156964]
      3.Manns, J M JM, Brenna, K J KJ, Colman, R W RW and Sheth, S B SB. 2002-05 Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases. [PMID:12038792]
      4.Martinez, Sergio E SE and 6 more authors. 2002-10-01 The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. [PMID:12271124]
      5.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      6.Bender, Andrew T AT, Ostenson, Cari L CL, Giordano, Daniela D and Beavo, Joseph A JA. 2004-03 Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression. [PMID:14687666]
      7.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      8.Seybold, Joachim J and 12 more authors. 2005-05-01 Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability. [PMID:15650061]
      9.Iffland, André A and 9 more authors. 2005-06-14 Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. [PMID:15938621]
      10.Kimura, Kouichi K and 31 more authors. 2006-01 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. [PMID:16344560]